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. 2022 Aug 18;13:4852. doi: 10.1038/s41467-022-32475-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The X-axis shows chromosome numbers. The Y-axis shows –log₁₀(P-value) of methylation to AD diagnosis association in the blood (above X-axis) or methylation to AD neuropathology (Braak stage) association in the brain (below X-axis). The genes corresponding to the top 20 most significant CpGs in blood or brain samples meta-analyses are highlighted. The P-values for brain sample meta-analysis were obtained from Zhang et al. (2020) (PMID: 33257653). The red line indicates a significance threshold of 5% False Discovery Rate for multiple comparison correction. All statistical tests are two-sided.