Table 1.
Cohort clinical characteristics in the total SCAD cohort and in subsets with/without CTD variants.
| Total SCAD cohort (n = 91) | SCAD cases carrying Tier 1 or Tier 2 CTD gene variants (n = 17) | SCAD cases not carrying Tier 1 or Tier 2 CTD variants (n = 74) | P-value† | |
|---|---|---|---|---|
| Mean age at first SCAD (y) | 45.4 | 40.8 | 46.5 | 0.028 |
| Female % | 91.2% | 94.1% | 90.5% | 1 |
| Mean Height (cm) | 167 | 167 (n = 16) | 167 (n = 72) | 0.92 |
| Mean BMI | 26.4 | 27.4 (n = 16) | 26.2 (n = 72) | 0.55 |
| Pregnancy-related SCAD* % (n/n female) | 12% (10/83) | 25% (4/16) | 9% (6/67) | 0.09 |
| Mean number of live births | 2.13 (n = 83) | 2.19 (n = 16) | 2.12 (n = 67) | 0.84 |
| >1 SCAD episode % (n) | 12.1% (11) | 23.5% (4) | 9.5% (7) | 0.21 |
| Comorbidities | ||||
| Connective tissue disorder % (n) | 2% (2) | |||
| Kidney disorder % (n) | 1% (1) | |||
| FMD % (n/n screened) | 27.9% (12/43) | 60% (3/5) | 23.7% (9/38) | 0.35 |
| Migraines % (n) | 46.2% (42) | 41.2% (7) | 47.3% (35) | 0.79 |
| T2 diabetes % (n) | 3.3% (3) | |||
| History of high cholesterol % (n) | 14.3% (13) | 17.6% (3) | 13.5% (10) | 0.70 |
| History of hypertension % (n) | 18.7% (17) | 11.8% (2) | 20.3% (15) | 0.51 |
| Physical stress % (n) | 15.4 (14) | 11.8% (2) | 16.2% (12) | 1 |
| History of anxiety/depression % (n) | 23.1% (21) | 35.3% (6) | 20.3% (15) | 0.21 |
| Chronic emotional stress % (n) | 50.5% (46) | 41.2% (7) | 52.7% (39) | 0.43 |
| Acute emotional stress % (n) | 4.4% (4) | |||
| Heart disease % (n) | 5.5% (5) | |||
| Dissection of the carotid or vertebral arteries % (n) | 6.6% (6) | |||
| Aneurysm % (n) | 4.4% (4) | |||
| Stroke % (n) | 2.2% (2) | |||
| Deep vein thrombosis % (n) | 3.3% (3) | |||
| Family history | ||||
| Heart disease % (n) | 72.5% (66) | 64.7% (11) | 74.3% (55) | 0.55 |
| Dissection of any artery % (n) | 4.4% (4) | |||
| Connective tissue disorder % (n) | 1.1% (1) | |||
| Aneurysm % (n) | 24.2% (22) | 35.3% (6) | 21.6% (16) | 0.34 |
| FMD % (n) | 2.2% (2) | |||
FMD, Fibromuscular dysplasia.
*
Gestation through to 5 months post-partum
†
P-values refer to comparisons between variant carriers and non-carriers, determined by t-tests for continuous variables and Fisher’s Exact for proportions, which were tested only when at least 10 cases meeting the criteria were observed.