Figure 3.

The formation of the epigenetic domain is determined by SS kinetics with $k^{+}=0.01/{\tau }_r$ for Scheme I, where spreading occurs only through 1D, and Scheme II, where 3D spreading dominates. (Left) Average (over an ensemble of trajectories) states of nucleosomes as a function of time. (Right) Mean values of the spin states of the nucleosomes. These are the profiles that show the extent of inactive domain formation. The value of k⁺/k⁻ = 10,000 in all simulations, while α(I) = 2.23⋅10⁻⁴ and α(II) = 2⋅10⁻⁴. To see this figure in color, go online.