Figure 6.

Comparison between simulations performed using Scheme II in the SS regime at different k⁺/k⁻ values with experimental data for H3K9me3 domains in embryonic stem cells (41). The experimental data were divided into small and large domains by clustering. These domains differ in the size of the genomic length they cover, and we fit them using different k⁺/k⁻ ratios that control the spreading process. We show that the small experimental domains correspond to a range of k⁺/k⁻ parameters in our model (left), while a higher (k⁺/k⁻ = 1000) value is needed to account for the larger domain size shown on the right. The parameters are chosen to be $k^{+}=0.01/{\tau }_r$ and α = 2k⁻/k⁺. To see this figure in color, go online.