. Author manuscript; available in PMC: 2023 Aug 1.

Published in final edited form as: Circ Genom Precis Med. 2022 Jun 14;15(4):e003645. doi: 10.1161/CIRCGEN.121.003645

Table 4.

Associations of echocardiogram measures with FLNC_LOF

Echocardiogram measure	FLNC _LOF	Variant-negative control	p-value^*
Individuals with available studies (% of group)	32 (53%)	75,837 (44%)
LVEF [%]	52 ± 13	57 ± 9	0.001
LVIDd [cm]	4.9 ± 0.8	4.6 ± 0.7	0.02
IVSd [cm]	1.12 ± 0.21	1.08 ± 0.24	0.02

FLNC_LOF: FLNC loss-of-function variant group; LVIDd: left ventricular internal diameter and end-diastole; IVSd: interventricular septum dimension at end-diastole; LVEF: left ventricular ejection fraction.

p-values based on bootstrapped linear model adjusted for age, sex, and ancestry and adjusted for multiple comparisons (p<0.05 considered significant).