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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Trends Cancer. 2022 May 13;8(9):726–734. doi: 10.1016/j.trecan.2022.04.004

Figure 2. T cell exhaustion differentiation includes a point of no return after which impedes immunotherapy efforts.

Figure 2.

The spectrum of T cell exhaustion differentiation is influenced by the action of several key transcription factors that can either maintain T cells in an epigenetically plastic stem-like state or tip the balance toward terminal exhaustion. An epigenetic checkpoint determines the fate commitment of precursor exhausted T cells which can either become rejuvenated to maintain anti-tumor function or epigenetically fixed in a fully exhausted state.