Table 1.

Baseline Characteristics of Patients with HF

Variable / Cohort	UCSD	UCSF	Northwestern Medicine	BIOSTAT-CHF	CHARM-Alternative	CHARM-Added	PARADIGM-HF	CHARM-Preserved	TOPCAT
	(n=4064)	(n=1294)	(n=5055)	(n=884)	(n=654)	(n=922)	(n=7970)	(n=1060)	(n=2559)
Age (years)	59.3 ± 13.3	57.4 ± 15.4	68.9 ± 15.3	65.2 ± 11.2	65.9 ± 11.5	63.8 ± 11.7	63.8 ± 11.4	66.1 ± 11.4	68.9 ± 9.7
Female (%)	57.7	58.8	53.6	72.3	32.3	22.9	22.0	43.2	50.7
LVEF (%)	55 ± 17	n/a	49 ± 17	29 ± 14	29 ± 8	27 ± 8	30 ± 6	55 ± 9	57 ± 11
Diastolic BP (mmHg)	70 ± 14	68 ± 13	70 ± 12	77 ± 15	75 ± 11	72 ± 10	74 ± 10	74 ± 11	75 ± 11
Creatinine (mg/dl)	1.0 [0.8–1.5]	1.2 [0.8–1.8]	1.1 [0.9–1.6]	1.1 [0.9–1.4]	1.1 [0.9–1.4]	1.1 [0.9–1.3]	1.1 [0.9–1.3]	1.0 [0.8–1.3]	1.1 [0.9–1.3]
Blood urea nitrogen (mg/dl)	19.2 [13.2–29.0]	21.6 [14.5–35.8]	21.6 [15.2–31.6]	22.0 [14.6–34.2]	21.0 [16.0–29.4]	21.0 [16.0–27.0]	19.0 [15.0–24.0]	20.0 [15.7–26.6]	19.0 [14.8–25.2]
Albumin (g/dl)	3.6 ± 0.7	3.2 ± 0.7	3.7 ± 0.6	3.2 ± 0.9	-	-	4.3 ± 0.3	-	4.1 ± 0.5
White blood cell count (x103/l)	8.4 [6.2–11.5]	8.0 [6.1–11.0]	7.2 [5.6–9.1]	7.9 [6.4–9.6]	7.0 [5.9–8.4]	7.1 [5.8–8.6]	6.7 [5.6–8.1]	7.0 [5.8–8.4]	6.7 [5.6–8.0]
Hemoglobin (g/dl)	11.3 ± 2.6	11.6 ± 2.4	11.7 ± 2.1	13.3 ± 2.0	13.5 ± 1.7	13.8 ± 1.6	13.9 ± 1.6	13.4 ± 1.6	13.1 ± 1.7
RDW (%)	14.8 [13.7–16.5]	-	15.2 [14.0–16.8]	-	14.5 [13.6–15.7]	14.3 [13.5–15.3]	-	14.3 [13.4–15.4]	-
Platelets (x103/l)	204 [143–272]	194 [135–258]	223 [173–285]	221 [181–265]	223 [184–266]	217 [180–259]	193 [161–230]	227 [189–274]	222 [190–260]
MARKER-HF	−0.14 ± 0.20	−0.06 ± 0.19	−0.19 ± 0.16	−0.17 ± 0.17	−0.25 ± 0.08	−0.24 ± 0.08	−0.33 ± 0.07	−0.26 ± 0.08	−0.29 ± 0.11

Values reported as: Mean ± SD for normally distributed variables or as median and [IQR] for the others.