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. 2022 Aug 18;12:14087. doi: 10.1038/s41598-022-18404-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation and expression of STUB1 gene in TCGA dataset. (a) Contour plot illustrates the association of STUB1 with TMB and GEP. Blue and red represent under- and overexpression, respectively. TMB cut-off was set at 100 and GEP cut-off corresponds to 55th percentile value for pan-cancer cohort. (b) In-silico deconvolution analysis of bulk RNAseq data from TCGA was used to establish the association between STUB1 expression and different cell types. Deconvolution analysis was performed separately for each tumor type. (c) Expression of STUB1 in tumor tissue and adjacent normal tissue is compared across tumor types for which both tumor and adjacent normal samples are available in TCGA dataset. The significance of the difference is indicated with *P ≤ 0.05, **P ≤ 0.01, and ****P ≤ 0.0001.