Table 5.
Enrichment results of gene-peak correlations.
| Peak | Enrichment term (term_id) | Term sizea | Intersectionb | Correlation set | Adjusted p value (SCS)c | Enriching genesd |
|---|---|---|---|---|---|---|
| 1 | Peptide GPCRs (WP:WP24) | 75 | 11 | All | 0.004 | CCR1, CCR2, CCR5, CCR9, CXCR5, FPR3, GALR1, MC3R, MC4R, OXTR, TRHR |
| Rectum; glandular cells[High] (HPA:0400053) | 2641 | 66 | Negative | 0.026 | Supplementary Table 1 | |
| Peptide GPCRs (WP:WP24) | 75 | 7 | Negative | 0.033 | CCR1, CCR2, CCR5, CXCR5, FPR3, MC4R, TRHR | |
| GPCRs, Class A Rhodopsin-like (WP:WP455) | 256 | 20 | All | 0.037 | Supplementary Table 1 | |
| hSIR2-p53 complex (CORUM:2821) | 2 | 2 | Positive | 0.050 | SIRT1, TP53 | |
| SEC23–SEC24 adaptor complex (CORUM:7139) | 2 | 2 | Positive | 0.050 | SEC23A, SEC24B | |
| 2 | Receptor complex (GO:0043235) | 379 | 18 | Positive | 0.019 | Supplementary Table 1 |
| Regulation of actin cytoskeleton (KEGG:04810) | 217 | 12 | Positive | 0.028 | BAIAP2, F2R, FGF17, FGFR1, FGFR3, ITGAD, ITGAX, ITGB5, PIK3R1, PIP5K1B, PPP1CC, PPP1R12B | |
| RNA polymerase I transcription regulatory region sequence-specific DNA binding (GO:0001163) | 8 | 3 | Negative | 0.043 | BAZ2A, PIH1D1, RRN3 | |
| RNA polymerase I core promoter sequence-specific DNA binding (GO:0001164) | 8 | 3 | Negative | 0.043 | BAZ2A, PIH1D1, RRN3 | |
| 3 | Intrinsic component of membrane (GO:0031224) | 2464 | 111 | All | 0.027 | Supplementary Table 1 |
| DTNBP1(1A)-HDAC3 complex (CORUM:7487) | 2 | 2 | Negative | 0.050 | DTNBP1, HDAC3 | |
| BKCA-beta2AR complex (CORUM:672) | 2 | 2 | Positive | 0.050 | ADRB2, KCNMA1 | |
| 4 | Intrinsic component of membrane (GO:0031224) | 2464 | 110 | All | 0.003 | Supplementary Table 1 |
| Inflammatory bowel disease (KEGG:05321) | 63 | 7 | Negative | 0.003 | GATA3, IL12B, IL12RB2, IL6, MAF, NFKB1, RORC | |
| Chromatin silencing complex (GO:0005677) | 6 | 4 | All | 0.004 | BAHD1, BAZ2A, RRP8, SIRT2 | |
| Integral component of membrane (GO:0016021) | 2355 | 105 | All | 0.005 | Supplementary Table 1 | |
| Chromatin silencing complex (GO:0005677) | 6 | 3 | Positive | 0.018 | BAHD1, RRP8, SIRT2 | |
| Oxidoreductase activity, acting on the CH-NH2 group of donors (GO:0016638) | 17 | 4 | Negative | 0.035 | GLDC, GLUD1, LOXL4, PNPO | |
| BKCA-beta2AR complex (CORUM:672) | 2 | 2 | Positive | 0.050 | ADRB2, KCNMA1 | |
| 5 | ESR-mediated signaling (REACTOME: R-HSA-8939211) | 181 | 13 | Negative | 0.005 | AGO2, AREG, CXCL12, FKBP5, GNB4, GNG12, GPAM, IGF1R, JUN, PIK3R2, TFF1, TNRC6C, USF2 |
| Postsynaptic membrane (GO:0045211) | 103 | 8 | Positive | 0.022 | CACNG4, CDH2, CNTN2, DAGLA, DBN1, GRIK4, HIP1, KCNMA1 | |
| RFC complex (CORUM:277–279-2799) | 5 | 3 | All | 0.050 | RFC1, RFC2, RFC3 | |
| MSP58-RINT1 complex (CORUM:6314) | 5 | 2 | Negative | 0.050 | MCRS1, RINT1 | |
| 6 | Plasma membrane (GO:0005886) | 5 | 105 | Positive | 0.050 | Supplementary Table 1 |
| Cell periphery (GO:0071944) | 2 | 105 | Positive | 0.050 | Supplementary Table 1 | |
| Intrinsic component of plasma membrane (GO:0031226) | 4879 | 83 | All | 0.008 | Supplementary Table 1 | |
| Protein-arginine deiminase activity (GO:0004668) | 4971 | 3 | Negative | 0.018 | PADI2, PADI3, PADI4 | |
| Integral component of membrane (GO:0016021) | 1591 | 112 | All | 0.018 | Supplementary Table 1 | |
| Intrinsic component of membrane (GO:0031224) | 5 | 116 | All | 0.025 | Supplementary Table 1 | |
| SPG3A–SPG33 complex (CORUM:6525) | 2355 | 2 | Positive | 0.040 | ATL1, ZFYVE27 |
Significant values are in [bold].
Enriched terms for genes that positively or negatively correlate with the identified peaks.
aThe term size indicates the number of genes belonging to a specific term in the relative dataset.
bThe intersection refers to the number of genes from the correlation analysis that overlaps with a specific term.
cSCS correction method embedded in gProfiler2.
dThe complete list of genes enriching for the named term is reported in the Supplementary Table 1.