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. 2022 Aug 18;13:4696. doi: 10.1038/s41467-022-32262-8

Fig. 5. Structure of the Gamma variant NTD reveals rearrangement of the N1 loop.

Fig. 5

a Global cryo-EM density map of the Gamma variant S protein bound to 4A8 at 2.59 Å (left), and a focus-refined map and model for the Gamma NTD-4A8 complex at 2.66 Å (right). b Superposition of 4A8-bound Gamma and wild-type NTD models showing N1 loop rearrangement. The three loops (N1, N3, N5) comprising the “NTD neutralization supersite” are indicated with circles. c Positioning of the L18→F, D138→Y, and T20→N mutations and adjacent residues in the Gamma NTD. d Superposition of residues shown in c with WT residues demonstrates steric incompatibilities. Areas of steric clashes are indicated by dashed ovals. Mutated residues are indicated as boxed labels. The wild-type—4A8 model (PDB: 7C2L) was used for all superpositions and is shown in gray throughout the figure.