TABLE 2.

Top 6 small molecular drug candidates for HCC treatments.

Name	Cell line	Major introduction	Major function	Correlation score
Mebendazole	Huh7	Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. It is used commonly for parasitic worm infections.	Tubulin inhibitor	−0.57
Albendazole	Huh7	Albendazole is a benzimidazole medication used for the treatment of a variety of parasitic worm infestations.	Tubulin inhibitor	−0.52
Vinorelbine	Huh7	Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.	Tubulin inhibitor	−0.52
Vinblastine	HepG2	Antitumor alkaloid isolated from Vinca rosea. It binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle.	Tubulin inhibitor	−0.52
Vindesine	Huh7	Vindesine is an anti-mitotic vinca alkaloid used in chemotherapy. It is used to treat many different types of cancer.	Tubulin inhibitor	−0.50
Vincristine	Huh7	Vincristine is a vinca alkaloid and used as a chemotherapy drug. It has a role as a tubulin modulator, a microtubule-destabilizing agent.	Tubulin inhibitor	−0.46