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This study suggests a possible scenario that olanzapine can induce changes in the levels of short-chain fatty acids (SCFAs) by altering the abundance and composition of gut microbiota, thereby reducing 5-HT secretion in the gut and related glutamatergic signal transduction through vagus nerve, which increases the ratio of hypothalamic orexotropic-related neuropeptide Y/agouti-related peptide (NPY/AgRP), eventually in turn contributing to accumulated lipid deposition in rats.
