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Phenotypic correction of tail clip in FVIII–/– mice treated with AAV8/hFVa vectors.
| Mice treatment | N | aPTT time (s) pre-treatment | aPTT time (s) before tail clip | Survived/Ratio (%) | Blood loss (g/kg body weight) |
| Naïve FVIII–/– | 13 | 114 ± 6.9 (104–124) | NA | 8 (61%) | 34.5 ± 12.9 |
| AAV8.FVa | 44 | 113 ± 5.8 (102–132) | 99.1 ± 10.0 (82–118)* | 42 (95%)** | 8.7 ± 7.2** |
| WT | 7 | NA | NA | 7 (100%) | 4.9 ± 4.4 |
* Compared with naive FVIII–/– aPTT of pre-treatment. ** Compared with naive FVIII–/–, P < 0.01.
