Table 1.
Related information of included traits in the Mendelian randomization analyses.
| Trait | Variable type | Consortium | Ancestry |
|---|---|---|---|
| Type 2 diabetes | Exposure | eQTLGen | European |
| Fasting glucose | Exposure | MAGIC | European |
| Fasting insulin | Exposure | MAGIC | European |
| Body mass index | Exposure | GIANT | European |
| Waist-to-hip ratio | Exposure | GIANT | European |
| High-density cholesterol | Exposure | GLGC | Trans-ancestry |
| Low-density cholesterol | Exposure | GLGC | Trans-ancestry |
| Triglycerides | Exposure | GLGC | Trans-ancestry |
| Total cholesterol | Exposure | GLGC | Trans-ancestry |
| Systolic blood pressure | Exposure | ICBP | European |
| Diastolic blood pressure | Exposure | ICBP | European |
| Pulse pressure | Exposure | ICBP | European |
| Alkaline phosphatase | Exposure | UK Biobank | European |
| Alanine aminotransferase | Exposure | UK Biobank | European |
| Gout | Disease outcome | GUGC | European |
| Serum urate | Continuous outcome | GUGC | European |
MAGIC, The Meta-Analyses of Glucose and Insulin-related traits Consortium; GIANT, Genetic Investigation of ANthropometric Traits consortium; ICBP, International Consortium for Blood Pressure; GLGC, Global Lipids Genetic Consortium; GUGU, Global Urate Genetics Consortium.