Table 2.

Mendelian randomization estimates of glycemic traits on serum urate or gout.

Outcome	Exposure	Method	Estimate	95% CI	P-value	MR-Egger intercept (P-value)
Serum urate	T2DM	IVW MR	0.027	-0.007-0.061	0.116	0.004 (0.112)
		Weighted median	0.029	-0.001-0.059	0.058
		MR-Egger	-0.029	-0.104-0.046	0.456
		MR-PRESSO	0.052	0.029-0.080	<0.001
	FBG	IVW MR	-0.089	-0.382-0.204	0.551	0.005 (0.494)
		Weighted median	-0.028	-0.170-0.115	0.702
		MR-Egger	-0.268	-0.854-0.318	0.377
		MR-PRESSO	0.017	-0.116-0.15	0.802
	FI	IVW MR	0.802	0.514-1.090	<0.001	0.005 (0.723)
		Weighted median	0.891	0.603-1.179	<0.001
		MR-Egger	0.483	-1.272-2.237	0.597
		MR-PRESSO	0.813	0.577-1.049	<0.001
Gout	T2DM	IVW MR	0.925	0.835-1.026	0.140	0.002 (0.816)
		Weighted median	1.001	0.836-1.199	0.988
		MR-Egger	0.903	0.719-1.135	0.383
		MR-PRESSO	0.943	0.855-1.040	0.240
	FBG	IVW MR	0.680	0.334-1.385	0.288	<0.001 (0.993)
		Weighted median	1.056	0.467-2.389	0.896
		MR-Egger	0.676	0.159-2.870	0.599
		MR-PRESSO	0.888	0.478-1.647	0.708
	FI	IVW MR	3.293	1.030-10.532	0.045	-0.002 (0.968)
		Weighted median	4.106	0.952-17.705	0.058
		MR-Egger	3.803	0.789-18.324	0.716
		MR-PRESSO	3.293	1.030-10.532	0.062

T2DM, type 2 diabetes; FBG, fasting glucose; FI, fasting insulin.