Table 4.

Mendelian randomization estimates of blood lipid on serum urate or gout.

Outcome	Exposure	Method	Estimate	95% CI	P-value	MR-Egger intercept (P-value)
Serum urate	HDL	IVW MR	-0.120	-0.188- -0.053	<0.001	-0.007 (0.015)
		Weighted median	-0.094	-0.150- -0.038	<0.001
		MR-Egger	0.013	-0.111-0.136	0.841
		MR-PRESSO	-0.139	-0.184- -0.095	<0.001
	LDL	IVW MR	-0.032	-0.087-0.022	0.243	-0.004 (0.125)
		Weighted median	-0.009	-0.055-0.036	0.691
		MR-Egger	0.020	-0.065-0.105	0.654
		MR-PRESSO	-0.012	-0.050-0.027	0.555
	TG	IVW MR	0.196	0.110-0.282	<0.001	0.009 (0.376)
		Weighted median	0.095	0.031-0.159	0.024
		MR-Egger	0.162	0.025-0.299	0.034
		MR-PRESSO	0.127	0.067-0.186	<0.001
	TC	IVW MR	-0.030	-0.109-0.049	0.461	-0.005 (0.176)
		Weighted median	-0.047	-0.103-0.010	0.106
		MR-Egger	0.068	-0.093-0.228	0.411
		MR-PRESSO	-0.035	0.081-0.012	0.149
Gout	HDL	IVW MR	0.747	0.612-0.912	0.004	-0.013 (0.121)
		Weighted median	0.873	0.653-1.167	0.359
		MR-Egger	0.960	0.662-1.391	0.829
		MR-PRESSO	0.759	0.626-0.920	0.006
	LDL	IVW MR	0.894	0.744-1.075	0.235	-0.003 (0.710)
		Weighted median	0.971	0.753-1.253	0.821
		MR-Egger	0.934	0.697-1.249	0.645
		MR-PRESSO	0.888	0.742-1.062	0.198
	TG	IVW MR	1.370	1.064-1.765	0.015	0.009(0.376)
		Weighted median	1.006	0.723-1.401	0.971
		MR-Egger	1.189	0.795-1.778	0.404
		MR-PRESSO	1.370	1.064-1.765	0.015
	TC	IVW MR	0.895	0.729-1.098	0.288	-0.006 (0.532)
		Weighted median	0.809	0.609-1.073	0.143
		MR-Egger	1.007	0.661-1.522	0.975
		MR-PRESSO	0.882	0.728-1.069	0.206

HDL, high-density cholesterol; LDL, low-density cholesterol; TG, triglycerides; TC, total cholesterol.