Table 5.

Mendelian randomization estimates of blood pressure on serum urate or gout.

Outcome	Exposure	Method	Estimate	95% CI	P-value	MR-Egger intercept (P-value)
Serum urate	SBP	IVW MR	0.015	0.005-0.024	0.003	-0.002 (0.717)
		Weighted median	0.016	0.006-0.027	0.002
		MR-Egger	0.024	-0.029-0.076	0.376
		MR-PRESSO	0.017	0.008-0.026	<0.001
	DBP	IVW MR	0.014	-0.007-0.035	0.183	0.001 (0.790)
		Weighted median	0.010	-0.011-0.030	0.365
		MR-Egger	0.005	-0.068-0.077	0.896
		MR-PRESSO	0.007	-0.011-0.024	0.450
	PP	IVW MR	0.005	-0.010-0.019	0.518	-0.009 (0.076)
		Weighted median	0.002	-0.014-0.018	0.773
		MR-Egger	0.061	-0.002-0.125	0.061
		MR-PRESSO	0.011	-0.002-0.023	0.099
Gout	SBP	IVW MR	1.064	1.021-1.108	0.003	0.007 (0.783)
		Weighted median	1.063	1.060-1.123	0.031
		MR-Egger	1.031	0.821-1.294	0.793
		MR-PRESSO	1.061	1.020-1.104	0.005
	DBP	IVW MR	1.017	0.927-1.116	0.721	-0.001 (0.963)
		Weighted median	1.018	0.910-1.138	0.759
		MR-Egger	1.025	0.743-1.413	0.883
		MR-PRESSO	1.001	0.943-1.063	0.966
	PP	IVW MR	1.089	1.024-1.158	0.006	-0.020 (0.334)
		Weighted median	1.100	1.005-1.204	0.039
		MR-Egger	1.242	0.946-1.630	0.123
		MR-PRESSO	1.091	1.032-1.153	0.003

SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure.