Table 2.
Halfmaximal activities of ELQs against E. multilocularis metacestodes and Reuber rat hepatoma cells.
| ELQ | EC50 metacestodes | IC50 Rh preconfluent | IC50 Rh confluent |
|---|---|---|---|
| 121 | 1.19 (0.52) | >30 | >30 |
| 136 | 0.22 (0.03) | >30 | >30 |
| 271 | 0.24 (0.13) | 8.64 (1.05) | >30 |
| 400 | 1.06 (0.60) | 1.46 (0.17) | >30 |
| 437 | 1.71 (0.01) | >30 | >30 |
The first number indicates the ELQ numbers. Efficacy against metacestodes (isolate H95) was assessed by PGI assay (relative to the positive control Tx-100) and EC50 values are given in μM (concentration range tested: 30–0.12 μM). Activity against mammalian cells (Reuber rat hepatoma cells, Rh) was assessed by Alamar blue assay (relative to the DMSO control), and IC50 values are given for preconfluent and confluent cells is given in μM (range tested: 30–0.23 μM). All tests were performed twice with triplicates for each concentration, and respective mean relative values are given with standard deviations in parentheses.