Table 3.
The associations between serum albumin-corrected calcium and the risk of first stroke in various subgroups*.
| Subgroups | Cases/controls | OR (95% CI) of calcium tertiles | P for interaction | ||
|---|---|---|---|---|---|
| T1 (<8.7) | T2 (8.7–9.1) | T3 (≥9.1) | |||
| Sex | 0.790 | ||||
| Male | 621/621 | 1.39 (1.05, 1.85) | Ref. | 1.39 (1.03, 1.89) | |
| Female | 634/634 | 1.36 (1.01, 1.83) | Ref. | 1.24 (0.94, 1.64) | |
| Age, y | 0.690 | ||||
| <65 | 304/304 | 1.34 (0.88, 2.04) | Ref. | 1.14 (0.73, 1.78) | |
| ≥65 | 951/951 | 1.38 (1.09, 1.75) | Ref. | 1.37 (1.09, 1.72) | |
| BMI, kg/m2 | 0.607 | ||||
| <24 | 328/404 | 1.12 (0.76, 1.65) | Ref. | 1.17 (0.81, 1.70) | |
| ≥24 | 927/851 | 1.47 (1.15, 1.87) | Ref. | 1.38 (1.08, 1.76) | |
| Current smoking | 0.824 | ||||
| No | 959/1000 | 1.37 (1.09, 1.73) | Ref. | 1.34 (1.07, 1.69) | |
| Yes | 296/255 | 1.30 (0.83, 2.04) | Ref. | 1.09 (0.68, 1.73) | |
| Current alcohol drinking | 0.681 | ||||
| No | 960/938 | 1.30 (1.02, 1.65) | Ref. | 1.28 (1.02, 1.62) | |
| Yes | 295/317 | 1.58 (1.04, 2.38) | Ref. | 1.45 (0.93, 2.26) | |
| Fasting glucose, mmol/L | 0.889 | ||||
| <7.0 | 896/1032 | 1.35 (1.07, 1.70) | Ref. | 1.26 (1.00, 1.59) | |
| ≥7.0 or history of diabetes# | 359/223 | 1.37 (0.88, 2.12) | Ref. | 1.43 (0.92, 2.23) | |
| Total cholesterol, mmol/L | 0.615 | ||||
| <5.8 (median) | 641/613 | 1.27 (0.96, 1.69) | Ref. | 1.35 (1.01, 1.80) | |
| ≥5.8 | 614/642 | 1.49 (1.10, 2.01) | Ref. | 1.28 (0.96, 1.72) | |
| SBP, mmHg | 0.846 | ||||
| <151.3 (median) | 528/721 | 1.39 (1.04, 1.86) | Ref. | 1.38 (1.03, 1.85) | |
| ≥151.3 | 727/534 | 1.34 (1.00, 1.80) | Ref. | 1.22 (0.91, 1.62) | |
| Magnesium, mg/L | 0.808 | ||||
| <19.9 (median) | 654/601 | 1.30 (0.99, 1.71) | Ref. | 1.29 (0.94, 1.76) | |
| ≥19.9 | 601/654 | 1.39 (1.02, 1.90) | Ref. | 1.30 (0.99, 1.71) | |
| Phosphate, mmol/L | 0.993 | ||||
| <1.2 (median) | 590/593 | 1.33 (0.99, 1.78) | Ref. | 1.28 (0.94, 1.73) | |
| ≥1.2 | 665/662 | 1.41 (1.05, 1.89) | Ref. | 1.33 (1.01, 1.76) | |
| 25(OH)D3, ng/mL | 0.526 | ||||
| <23.2 (median) | 635/616 | 1.35 (1.01, 1.80) | Ref. | 1.21 (0.90, 1.62) | |
| ≥23.2 | 620/639 | 1.34 (1.00, 1.80) | Ref. | 1.41 (1.06, 1.89) | |
*
ORs of first stroke in relation to serum albumin-corrected calcium levels (tertiles) were calculated using multivariate logistic regression models. Each subgroup analysis adjusted, if not stratified, for age, sex, BMI, BMI, SBP, DBP, smoking status, drinking status, labor intensity, total cholesterol, triglycerides, HDL-C, fasting glucose, total homocysteine, eGFR, phosphate, 25(OH)D3, magnesium, antihypertensive drugs, glucose-lowering drugs, lipid-lowering drugs, antiplatelet drugs, except for the stratifying variable.
#
History of diabetes was defined as self-reported diabetes, or use of anti-diabetic medications.