TABLE 3.
Application of polymer monolithic columns in medicine.
| Monolithic materials | Initiator | Matrix | Type of column | Analytical method | LOD | Recovery | Ref |
|---|---|---|---|---|---|---|---|
| Allyl-β-CD-MMA/TAIC-EDMA | AIBN | crude extract of ephedra, lipopeptide antibiotics | stainless steel column | HPLC | 1 ng/ml | 100.27–103.77% 97.30–101.33% | Zhao et al. (2021) |
| poly (DES-EGDMA) | AIBN | NSAIDs in spiked human plasma samples | capillary column | online in-tube SPME-HPLC | 0.05–0.5 ng/ml | 84.5–105.5% | Wang et al. (2018a) |
| poly (ethylene glycol dimethacrylate-N-methacryloyl-(L)-phenylalanine methyl ester) (MIP S-CIT) | AIBN | enantioseparation of R,S-citalopram (R,S-CIT) in an aqueous solution | capillary column | CE + HPLC | — | — | Derazshamshir et al. (2021) |
| DAIP-co-EDMA | AIBN | tussilagone in farfarae flos | stainless-steel column | SPE-HPLC | 0.2 μg/ml | 100.3–100.6% | Wang L. et al. (2021) |
| AAPBA-co-DVB-co-MBAA | AIBN | benzimidazoles in animal | capillary column | in-tube SPME-MS | 0.55–0.91 ng/g | 72.5–92.4% | Wu F. et al. (2021) |
| poly (GMA-SMX-co-EDMA) | AIBN | eight aromatic ketones and trypsin | capillary column | micro-HPLC | — | — | Xiao et al. (2015) |
| AM-co-GMA-co-MBA-co-AMPS | AIBN | fifive alkaloids (piperine, nuciferine, kukoline, Berberine, tetrandrine) | capillary column | CEC | 0.02–0.1 ug/ml | 93.4–108.0% | Chen et al. (2016) |
| poly (hexyl methacrylate) | AIBN | paracetamol and Chlorzoxazone | capillary column | nano-LC–UV | 0.09–0.2 ug/ml | 98.32–102.28% | Salih et al. (2018) |
| (PHEA/TMPTA-EDMA) | AIBN | dioscin in human plasma | stainless steel column | SPE-HPLC-UV | — | 96.61–113.73% | Peng et al. (2020) |
| poly (GMA-EDMA) | — | caffeic acid phenylamide, chlorogenic acid, piceatannol, nor-NOHA acetate | capillary column | HPLC | — | — | Andre and Guillaume, (2021) |
| polymyxin-B | AIBN | 50 racemic pharmaceutical drugs | capillary column | nano-HPLC | — | — | Ghanem et al. (2022) |
3-Acrylamidophenylboronic acid (AAPBA); divinylbenzene (DVB); N, N′-Methylenebisacrylamide (MBAA); mass spectrometry (MS); ß-cyclodextrin (β-CD); methacrylate (MMA); ethylene dimethacrylate (EDMA); triallyl isocyanurate (TAIC); S-citalopram (S-CIT); R,S-citalopram (R,S-CIT); molecularly imprinted polymer (MIP); paracetamol (PAR); chlorzoxazone (CZN); liquid chromatography (LC); deep eutectic solvent (DES); ethylene glycol dimethacrylate (EGDMA); non-steroidal anti-inflflammatory drugs (NSAIDs); acrylamide (AM); glycidyl methacrylate (GMA); N,N′-methylenebisacrylamide (MBA); 2-acrylamido-2-methyl-1-propane-sulfonic acid (AMPS); capillary electrochromatography (CEC); sulfamethoxazole (SMX); diallyl isophthalate (DAIP); phenyl ether acrylate (PHEA); trimethylolpropane triacrylate (TMPTA).