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. 2022 Aug 5;13:941608. doi: 10.3389/fimmu.2022.941608

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Copyright © 2022 Qin, Liu, Zhou, Jin, Gong, Liu, Chen, Huang, Fan, Tao and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TIM-4 interference inhibits the EMT process in the NP model. (A) TIM-4⁺ cells (green), TIM-4⁺/CD68⁺ cells (yellow), and TGF-β1 (red) in the mouse sinonasal mucosa were detected by immunofluorescence. E-cadherin, α-SMA, and Vimentin in the mouse sinonasal mucosa were detected by IHC. (B) Quantitative summary of the number of TIM-4⁺ cells in the mouse sinonasal mucosa. (C) Quantitative summary of the number of TIM-4⁺/CD68⁺ cells in the mouse sinonasal mucosa. (D) Quantitative summary of the intensity of TGF-β1 in the mouse sinonasal mucosa. (E) Quantitative summary of the intensity of E-cadherin in the mouse sinonasal mucosa. (F) Quantitative summary of the intensity of α-SMA in the mouse sinonasal mucosa. (G) Quantitative summary of the intensity of Vimentin in the mouse sinonasal mucosa. (H-K) The TGF-β1, MMP2, MMP7, and MMP9 levels in the nasal lavage fluid were detected by ELISA. PBS group: n=6; OVA+SEB group: n=7; OVA+SEB+TIM-4 mAb group: n=5; OVA+SEB+DXM group: n=6. IHC and immunofluorescence representative pictures are shown at a magnification of 400×. The insets show a higher magnification of the selected area. Bars show the mean ± SD. *P<0.05, **P<0.01,***P<0.001. ns, no significance.