Table 1.

Compounds or Molecules Inhibiting the Pyroptosis Signaling Pathway for the Treatment and Management of Diabetic Wound.

Classification	Mechanism of Pyroptosis Inhibition	References
Glyburide	NLRP3/caspase-1/IL-1β/IL-18/ASC	(92)
Bacillus subtilis (WB800N)	NLRP3/caspase-1/IL-1β/IL-37/TLR2/ASC	(93)
Perforin-2	AIM2/GSDMD/IL-1β/ASC	(94)
Bletilla striata polysaccharide	NLRP3/IL-1β/TNF-α/ROS	(95)
Paeoniflorin	NLRP3/caspase-1/IL-1β/IL-18/TNF-α/ASC	(96)
Heparan sulfate	NLRP3/IL-1β/IL-18/TNF-α/ASC	(97)

NLRP3, NOD-like receptor family pyrin domain containing 3; AIM2, Absent in melanoma 2; ASC, CARD-containing apoptosis-associated speck-like protein; IL-1β, interleukin-1beta; IL-18, interleukin-18; IL-37, interleukin-37; TLR2, Toll-like receptor-2; GSDMD, gasdermin D; TNF-α, Tumour Necrosis Factor alpha; ROS, reactive oxygen species.