Table 2.
Association between tissue iron levels and RCC patient survival outcomes.
| Tissue site | Time to Metastasis | Time to Cancer-Specific Mortality | Time to All-Cause Mortality | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariable | Univariate | Multivariable | Univariate | Multivariable | ||||||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| ccRCC patients | Tumor Cancer Cells | 0.45 (0.23, 0.87) | 0.013 | 0.63 (0.29, 1.37) | 0.24 | 0.70 (0.42, 1.17) | 0.17 | – | – | 0.77 (0.51, 1.16) | 0.21 | – | – |
| TME | 0.54 (0.27, 1.09) | 0.068 | – | – | 0.84 (0.49, 1.42) | 0.48 | – | – | 0.66 (0.43, 1.02) | 0.053 | – | – | |
| Benign renal epithelium | 3.02 (1.27, 7.17) | <0.001 | 4.95 (1.65, 14.88) | 0.004 | 3.46 (1.74, 6.89) | <0.001 | 1.71 (0.78, 3.75) | 0.18 | 2.17 (1.12, 4.17) | 0.028 | 1.12 (0.53, 2.37) | 0.76 | |
| non-ccRCC patients | Tumor Cancer Cells | 0.45 (0.10, 2.06) | 0.22 | – | – | 0.65 (0.13, 3.21) | 0.50 | – | – | 2.18 (0.77, 6.11) | 0.12 | – | – |
| TME | 0.50 (0.09, 2.65) | 0.34 | – | – | 0.71 (0.16, 3.17) | 0.62 | – | – | 1.90 (0.65, 5.54) | 0.20 | – | – | |
| Benign renal epithelium | 1.82 (0.24, 14.07 | 0.78 | – | – | 1.04 (0.16, 6.96 | 0.79 | – | – | 1.57 (0.45, 5.46) | 0.60 | – | – | |
Hazard ratios (HR) refer to iron levels (H-scores) above the median. Multivariable analysis was performed only if time to event was significant on univariate analysis. CI, confidence interval; TME, tumor microenvironment. Bold p-values signify statistical significance.