Table 9.

13-week toxicity study in rats. Hematology. Group mean values and standard deviation of males (M) and females (F). Significantly different from the controls: ∗: P < 0.05; ∗∗: P < 0.01. N = 8–10 for females; N = 6–9 for males.

		Hct	Hb	RBC	Retic	MCH	MCHC	MCV	RDW	WBC	N	L	E	B	M	LUC	Plt	PT	APTT
		L/L	g/dL	x1012/L	x1012/L	pg	g/dL	fL	%	x109/L	x109/L	x109/L	x109/L	x109/L	x109/L	x109/L	x109/L	sec	sec
1M	Mean	0.454	15.6	8.31	0.148	18.8	34.5	54.7	12.7	8.27	1.17	6.67	0.10	0.06	0.21	0.07	610	22.0	14.5
	SD	0.0156	0.47	0.299	0.0222	0.72	0.60	2.03	0.84	1.213	0.276	1.048	0.025	0.019	0.070	0.014	58.7	1.15	2.17
2M	Mean	0.457	16.0	8.21	0.141	19.5	35.0	55.7	12.5	9.11	2.20	6.42	0.11	0.06	0.24	0.07	545	25.0	16.3
	SD	0.0146	0.43	0.320	0.0167	0.82	0.88	1.67	0.65	2.658	2.280	1.050	0.045	0.033	0.128	0.016	93.2	6.00	1.86
3M	Mean	0.470	15.9	8.65	0.146	18.4	33.9	54.4	12.7	7.77	1.64	5.69	0.11	0.06	0.21	0.05	601	27.7	15.0
	SD	0.0162	0.39	0.403	0.0160	0.65	0.71	1.33	0.41	2.467	1.311	1.270	0.079	0.041	0.142	0.028	57.2	14.12	1.48
4M	Mean	0.454	15.7	8.50	0.126∗	18.4	34.5	53.5	12.5	9.56	3.84	5.20∗∗	0.10	0.07	0.27	0.07	559	24.5	16.2
	SD	0.0165	0.66	0.372	0.0124	0.63	0.71	0.89	0.49	3.567	3.099	0.742	0.042	0.041	0.116	0.032	61.9	4.48	2.36
1F	Mean	0.415	14.8	7.40	0.167	20.0	35.6	56.0	10.9	5.03	0.90	3.95	0.11	0.01	0.12	0.03	828	20.0	19.9
	SD	0.0223	0.68	0.355	0.0259	0.48	0.71	1.12	0.24	1.105	0.216	1.101	0.046	0.005	0.043	0.014	131.4	3.93	6.54
2F	Mean	0.426	15.1	7.85∗	0.152	19.2	35.4	54.3∗∗	10.9	4.09	0.60	3.21	0.06	0.01	0.09	0.02	836	21.5	18.1
	SD	0.0121	0.59	0.277	0.0194	0.93	1.11	1.37	0.86	1.054	0.387	0.702	0.020	0.011	0.031	0.008	89.1	2.59	5.68
3F	Mean	0.429	15.0	7.69∗	0.149	19.5	35.0	55.8	10.6∗	5.83	1.31	4.23	0.07	0.02	0.16	0.04	836	19.4	18.5
	SD	0.0113	0.29	0.285	0.0142	0.53	0.60	1.25	0.15	1.336	1.055	0.734	0.026	0.012	0.066	0.010	145.0	1.67	2.48
4F	Mean	0.424	15.0	7.62∗	0.164	19.7	35.4	55.7	10.6∗	4.06	0.91	2.92∗	0.09	0.02	0.10	0.03	812	21.0	19.1
	SD	0.0194	0.64	0.319	0.0284	0.63	1.02	0.88	0.34	1.642	0.692	1.091	0.032	0.008	0.060	0.023	75.3	3.87	6.02

Hematocrit (Hct), Hemoglobin concentration (Hb), Erythrocyte count (RBC), Absolute reticulocyte count (Retic), Mean cell hemoglobin (MCH), Mean cell hemoglobin concentration (MCHC), Mean cell volume (MCV), Red cell distribution width (RDW), Total leucocyte count (WBC), Differential leucocyte count: Neutrophils (N), Lymphocytes (L), Eosinophils (E), Basophils (B), Monocytes (M), Large unstained cells (LUC), Platelet count (Plt), Prothrombin time (PT), Activated partial thromboplastin time (APTT).