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. 2022 Aug 5;13:937095. doi: 10.3389/fpls.2022.937095

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Copyright © 2022 Morey and Peebles.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biosynthesis of strictosidine, the common precursor of all terpenoid indole alkaloids. Enzyme abbreviations are as follows: AACT (acetoacetyl-CoA thiolase), AS (anthranilate synthase), CPR (cytochrome P450 reductase), CYP72A1v3 (cytochrome P450 reductase), DXR (1-deoxy-D-xylulose-5-phosphate reductoisomerase), DXS (1-deoxy-d-xylulose-5-phosphate synthase), G10H (geraniol 10-hydroxylase), GES (geraniol synthase), GPPS (geranyl diphosphate synthase), HMGR (hydroxymethyglutaryl-CoA reductase), HMGS (hydroxymethyglutaryl-CoA synthase), IGPS (indole-3-glycerol phosphate synthase), IPI (isopentenyl diphosphate isomerase), MVD (mevalonate 5-diphosphate decarboxylase), MVK (mevalonate kinase), PAT (phosphoribosylanthranilate transferase), PAI (phosphoribosyl anthranilate isomerase), PMK (mevalonate 5-phosphate kinase), SLS (secologanin synthase), STR (strictosidine synthase), TDC (tryptophan decarboxylase), and TS (tryptophan synthase).