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. 2022 Aug 5;13:937095. doi: 10.3389/fpls.2022.937095

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Copyright © 2022 Morey and Peebles.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biosynthesis of terpenoid indole alkaloids starting from strictosidine. Enzyme abbreviations are as follows: 16OMT (16-hydroxytabersonine 16-O-methyltransferase), ASO (O-acetylstemmadenine oxidase), AVLBS (anhydrovinblastine synthase), CS (catharanthine synthase), D4R (desacetoxyvindoline 4-reductase), DAT (deacetylvindoline 4-Oacetyltransferase), DPAS (dihydroprecondylocarpine synthase), GO (geissoschizine oxidase), GS (geissoschizine synthase), HL1 (α/β hydrolase 1), HL2 (α/β hydrolase 2), HYS (heteroyohimbine synthase), NMT (N-methyltransferase), PAS (precondylocarpine acetate synthase), SAT (stemmadenine-O-acetyltransferase), SGD (strictosidine β-D-glucosidase), SS (serpentine synthase), T16H (tabersonine 16-hydroxylase), T19H (tabersonine 19-hydroxylase), T3O (tabersonine 3-oxidase), TEX1/2 (tabersonine 6,7-epoxidase), TR3 (tabersonine 3-reductase), and TS (tabersonine synthase).