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. 2022 Jul 30;55:102406. doi: 10.1016/j.redox.2022.102406

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — In vivo STOX1 model of preeclampsia and BH4 effect on placenta transcriptomics. (A)in vivo model of preeclampsia and preclinical trial using BH4 supplementation in healthy and preeclamptic pregnant mice. (B) Principal Component Analysis of gene expression in control and STOX1-overexpressing placentas at 16.5 days post-coïtum, with or without BH4 treatment. (C) Enrichment of gene expression of KEGG pathways in STOX1 placentas with or without BH4 treatment. (D) Enrichment of specific pathways related to placental function in this comparison. (E) BH4 rescues the alteration of gene expression induced by STOX1 overexpression in the placenta (threshold chosen: genes with more than two fold changes, and corrected to <30% of the value in control samples).