Fig. 6.

Cell proportions in the placenta are altered by BH4 treatment, and major endothelial genes are deregulated. (A) Using deconvolution, we were able to dissociate the different major cell types present in the mouse placenta. The proportion of cells was altered by BH4 for trophoblasts and for decidual stromal cells, while the other cell types did not differ quantitatively. (B) In the endothelial cells, several genes were deregulated. The column ‘Specificity’ refers to the endothelial specificity, with *** for genes expressed exclusively in the endothelium, while ** and * refers to genes that are expressed in other tissues, albeit predominantly in the endothelial cells.