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The summary of how DOP alleviates PCOS through gut–brain–ovary regulation. Dendrobium officinale polysaccharide can promote the remodeling of the gut microbiota and the production of butyrate bacterium in PCOS rats. High levels of butyrate through G protein-coupled receptor 41 to stimulate the secretion of PYY by entero-endocrine L-cells. PYY regulates the levels of steroid hormones through the gut–brain axis and ameliorates the polycystic ovary phenotype in PCOS rats.
