Figure 4.

RPA for TCGA cohort (n = 766). (A) RPA model defines 4 risk groups based on IDH mutation status, age at diagnosis, and SDL risk score. (B) Kaplan-Meier curves, number at risk, median OS, and HRs for the 4 risk groups as determined in (A). Group 1 has the worst OS, Group 2 and 3 have intermediate OS, and Group 4 has the best OS. (C) Kaplan-Meier curves, number at risk, and median OS of IDH-Wildtype split by Group 1 and Group 2. The solid two lines represent IDH-wildtype astrocytoma within Groups 1 and 2 resepectively whereas dashed represent IDH-wildtype GBM within Groups 1 and 2. HR, hazard ratio; OS, overall survival; SDL, survival deep learning; RPA, recursive partitioning analysis; IDH, isocitrate dehydrogenase; GBM, Glioblastoma multiforme.