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. 2022 Feb 15;4(1):vdac017. doi: 10.1093/noajnl/vdac017

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© The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — EVs from IFN-γ-treated glioblastoma cells cause superinduction of myeloid-derived suppressor cell (MDSC) and nonclassical monocyte (NCM) formation. Representative dot plots showing MDSC frequency (CD14⁺/HLA-DR⁻) (A) and NCM frequency (CD14⁺/PD-1⁺/CD16 +) (C) in monocytes in serum-free media, EVs, IFN-γ- (100 ng/mL) treated EVs (left lane, middle lane, right lane) from dBT cell lines. Bar graphs showing a significant induction in the mean frequency of CD14⁺/HLA-DR⁻ cells (B) and CD14⁺/PD1⁺/CD16⁺ cells (D). *P < .05, **P<0.01, ***P < .001, ****P < .0001. EVs, extracellular vesicles; IFN-γ, interferon-gamma.