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. 2022 Aug 18;140(10):946–954. doi: 10.1001/jamaophthalmol.2022.3131

Figure 2. Cumulative Proportion of Disease Worsening Through 4 Years by Baseline Diabetic Retinopathy Severity Scale (DRSS) Score on Masked Ultra-Widefield (UWF) Color Images.

Figure 2.

Worsening was defined by either a worsening of 2 or more steps on the DRSS within Early Treatment Diabetic Retinopathy Study (ETDRS) fields on masked UWF-color images or receipt of diabetic retinopathy (DR) treatment. Eyes receiving treatment with anti–vascular endothelial growth factor, steroid, or vitrectomy for conditions other than DR were censored after treatment initiation. Eyes not meeting the primary outcome or receiving non-DR treatment were censored at the last visit. The cumulative proportion of primary outcome was 45% (95% CI, 37%-54%) in eyes with baseline mild nonproliferative diabetic retinopathy (NPDR), 40% (95% CI, 32%-49%) with moderate NPDR, 26% (95% CI, 17%-38%) with moderately severe NPDR, and 43% (95% CI, 34%-53%) with severe or very severe NPDR.