Figure 2. Cumulative Proportion of Disease Worsening Through 4 Years by Baseline Overall Nonperfusion Index (NPI) on Ultra-Widefield Fluorescein Angiography (UWF-FA).

Worsening was defined by either a worsening of 2 or more steps on the Diabetic Retinopathy Severity Scale (DRSS) within Early Treatment Diabetic Retinopathy Study (ETDRS) fields on masked ultra-widefield (UWF) color images or receipt of diabetic retinopathy (DR) treatment. Eyes receiving treatment with anti–vascular endothelial growth factor, steroid, or vitrectomy for conditions other than DR were censored after treatment initiation. The cumulative proportion for primary outcome of disease worsening was 26% (95% CI, 15%-43%) in the no-nonperfusion group, and 43% (95% CI, 34%-52%), 38% (95% CI, 30%-47%), and 46% (95% CI, 38%-55%) in eyes with low nonperfusion, medium nonperfusion, and high nonperfusion, respectively. Eyes that did not meet the primary outcome or that received non-DR treatment were censored at the last visit. The Cox proportional hazards model was adjusted for baseline DRSS score within the ETDRS fields on masked UWF-color images, percentage of total imaged area on UWF-FA, and the correlation between the 2 study eyes from the same participant.