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. 2022 Jul 23;33(8):1494–1504. doi: 10.1021/acs.bioconjchem.2c00220

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© 2022 The Authors. Published by American Chemical Society

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Cross-neutralization of long α-neurotoxins using the C2 nanobody and Quad proteins. (A) Neutralization assessment against α-cbtx from N. kaouthia, LαNtxs present in venom fraction Nm8 from N. melanoleuca, α-eptx from D. polylepis, and α-bgtx from B. multicinctus. Error bars represent the ±SD of four replicates. (B) Binding affinity against neutralized LαNtxs characterized using FIDA. Binding profiles were measured as a change in the apparent hydrodynamic radius of the indicators (LαNtxs from N. kaouthia and N. melanoleuca) following addition of increased concentrations of Q187. The K_D values were calculated from the binding isotherm. Represented results are from a single experiment with technical repeats performed in duplicate.