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After gut microbiota imbalance, intestinal probiotics such as Bifidobacterium, Lactobacillus, Bacteroides, butyrate-producing bacteria decreased; the number of pathogenic bacteria such as Fusobacterium nucleatum, Enterotoxigenic fragile bacteria, Escherichia coli, Clostridium difficile, Klebsiella pneumonia, Desulphurization increased. The pathogenic bacteria secreted a large number of toxic factors to damage intestinal epithelial cells and promote the occurrence of CRC.
