Skip to main content
. 2022 May 3;2(4):274–294. doi: 10.1021/acsengineeringau.2c00008

Figure 7.

Figure 7

(a) Final equilibrated configurations of zwitterionic-AuNPs with different polymer chain lengths interacting with lipid membranes at (left) 50% and (right) 100% protonation degree, respectively. Water molecules are not displayed for clarity. The lipid headgroups are shown in blue, lipid tails in silver, gold core in yellow, PEG in green, the zwitterionic polymer in blue, and zwitterionic polymer after protonation in magenta. Adapted from ref (160). Copyright 2017 American Chemical Society. (b) PES-b-PCBMA/PES membrane (the blend of PES-b-PCBMA copolymer and PES homopolymer) formation process via nonsolvent induced phase separation (NIPS). Depicted are the initial state at (1) step 0; (2) step 20 000; (3) step 100 000; (4) step 20  000; (5) step 400 000. Brown green beads represent PES; orange beads represent the PES segments in the PES-b-PCBMA copolymer; and cyan depicts MMA segments (composed of A). Solvent D beads, water beads, and zwitterionic segment B beads are omitted for clarity. Adapted from ref (220). Copyright 2019 American Chemical Society. (c) Molecular structures of the 12 zwitterionic moieties studied. Adapted from ref (226). Copyright 2014 American Chemical Society. (d) (Left panel) One Levodopa molecule in the POPC-cholesterol bilayer. All the cholesterol molecules in the visualized lipid phase are depicted in the color blue, and again the Levodopa is portrayed in black color with green contour. (Right panel) Mass density profiles of the aqueous phase, cholesterol-free lipid phase consisting of DPPC molecules and Levodopa in its zwitterionic form along the normal to the two leaflets of the bilayer. Adapted with permission from ref (113). Copyright 2021 Elsevier.