Skip to main content
. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Nat Microbiol. 2021 Oct 25;6(11):1410–1423. doi: 10.1038/s41564-021-00973-1

Fig.2∣. High sensitivity of RifR rpoB H526Y to cell wall synthesis inhibitors and uracil analogs.

Fig.2∣

a, Sensitivity of the indicated strains to the cell wall synthesis and division inhibitor A22. Plating efficiency is based on colony forming unit (CFU) values. Mean and standard error are based on three biological replicates. *** p-value<0.001, **** p-value<0.0001. p-values are based on the student t-test (two-sided, equal variance) b, same as in (a) but with the uracil analog 5-fluorouridine (5FUd) c, growth inhibition across two-dimensional A22-5FUd concentration space for wild type and rpoB H526Y cells. d, Same as in (c) but with a combination of mecillinam and 5FU. e, The effect of a A22+5FUd combination in the presence of Rif. Growth of indicated strains across a Rif concentration gradient alone, with A22 (1μg/ml) and 5FUd (1μg/ml) separately or in combination.