Comparison of changes in iron, hematologic, and erythropoietic parameters in 6- to 7-week-old Townes sickle mice treated with 60 mg/kg vamifeport twice daily for 6 weeks and 8- to 12-week-old β-thalassemia intermedia (th3/⁺) mice³ treated with 30 or 100 mg/kg vamifeport twice daily for 36 days

Selected outcomes		Townes sickle mice		Th3/+ β-thalassemia mice
Parameter	Marker	Compared with control	Response to vamifeport	Compared with control	Response to vamifeport
Iron	Serum	High	↓	Similar	↓
	Liver	High	↔	High	↔
	Liver incorporation	High	↓	High	↓
Hematologic	Mean corpuscular hemoglobin concentration	Low	↓	Low	↑
	Mean corpuscular hemoglobin	High	↓	Low	↓
	Mean corpuscular volume	High	↓	Low	↓
	Red blood cells	Similar	↔	Low (slight)	↑
	Hemoglobin	Low	↔	Low	↑
Erythropoietic	Reticulocytes	High	↔	High	↓
	Splenic index	High	↓	High	↓
	Mature marrow erythrocytes	Low	↔	Low	↑

All mice were fed low-iron chow at the onset of treatment and received iron supplemented water in the 6-hour timeframe between vamifeport doses.