Table 1A:
Studies included in the meta-analysis of brain activation during rectal distention
| Author | Year | Imaging Modality | Subjects (number, sex) | Method of Rectal Distention | Subjects’ age range (mean or median, years) |
|---|---|---|---|---|---|
| Lotze | 2001 | fMRI | 8 females | Manual air inflation of balloon | 28–54 (37.3) |
| Hobday | 2001 | fMRI | 8 males | Mechanical air balloon inflation | 21–39 |
| Berman | 2006 | fMRI | 6 females, 7 males | Pressure-controlled barostat | 33.1 ± 10.9 (males); 34.8 +/− 7.9 (females) |
| Eickhoff | 2006 | fMRI | 4 females, 4 males | Manual air inflation of balloon | 37.3 |
| Song | 2006 | fMRI | 12 females | Pressure-controlled barostat | 23 |
| Rosenberger | 2009 | fMRI | 14 females | Pressure-controlled barostat | 32.78 ± 8.38 |
| Moisset | 2010 | fMRI | 11 females | Pressure-controlled barostat | 38.4 ±3.1 |
| Hall | 2010 | fMRI | 6 females | Pressure-controlled barostat | 30–40 |
| Elsenbruch | 2010 | fMRI | 12 females | Pressure-controlled barostat | 31.4 |
| Benson | 2012 | fMRI | 15 females, 15 males | Pressure-controlled barostat | 26.1 ± 8.3 (females); 25.4±3.8 (males) |
| Smith | 2011 | fMRI | 14 females | Pressure-controlled barostat | 19–53 (29) |
| Kotsis | 2012 | fMRI | 18 females, 18 males | Pressure-controlled barostat | 25.2 and 27.1 |
| Schmid | 2013 | fMRI | 18 females, 18 males | Pressure-controlled barostat | 35.3 and 24.1 |
| Bouhassira | 2013 | fMRI | 11 females | Pressure-controlled barostat | 41.5±12.8 |
| Rubio | 2015 | fMRI | 9 females, 6 males | Pressure-controlled barostat | 21–43 (24) |
| Schmid | 2015 | fMRI | 14 females and 14 males | Pressure-controlled barostat | 24 |
| Benson | 2015 | fMRI | 26 males | Pressure-controlled barostat | 26.3 ± 0.7 |