Table 2.
Association of serum TMAO with type 2 diabetes risk
| Tertiles of serum TMAO | P-trend | |||
|---|---|---|---|---|
| T1 (n = 696) | T2 (n = 696) | T3 (n = 696) | ||
| Median, μmol/L | 0.66 | 1.39 | 4.05 | |
| Case, n | 67 | 90 | 97 | |
| Person years | 5474 | 5420 | 5319 | |
| Model 1a | 1.00 (Ref) | 1.32 (0.96–1.82) | 1.47 (1.08–2.01) | 0.033 |
| Model 2b | 1.00 (Ref) | 1.17 (0.84–1.61) | 1.42 (1.03–1.96) | 0.031 |
TMAO trimethylamine-N-oxide; Ref, reference
P for trend was calculated by treating the median values of serum TMAO levels in tertiles as continuous values in Cox proportional hazard models
aModel 1: adjusted for age and sex
bModel 2: adjusted for model 1 plus household income, smoking status, alcohol drinking, tea drinking, hypertension, WHR, physical activity, intakes of total energy, egg, red and processed meat, fish and shellfish, serum levels of TG, HDL-C and fasting glucose