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. 2022 Aug 18;22:202. doi: 10.1186/s12866-022-02614-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Caspase activity and protease inhibition during light organ apoptosis in gravity and LSMMG conditions at 10 h post-inoculation. The activity of a executioner caspases 3/7, b extrinsic initiator caspase-8, and c intrinsic initiator caspase-9 was measured in the light organ of symbiotic (sym) hatchlings at 10 h in gravity (blue) and modeled microgravity (red). d Apoptosis was quantified in symbiotic hatchlings at 10 h in both conditions following protease inhibitor treatment including pan-caspase inhibitor z-VAD-FMK (ZVAD), the caspase 8 inhibitor Ac-IETD-CHO (C8i), caspase 9 inhibitor Ac-LEHD-CMK (C9i), Pefabloc (Pefa) and dimethyl sulfoxide (DMSO) controls. Error bars are the standard error of the mean. Asterisks denote significant differences between datasets (* = p ≤ 0.05, ** = p ≤ 0.01). Comparisons that were not significant are labeled “ns”