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. 2022 Aug 19;41:252. doi: 10.1186/s13046-022-02467-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — SLERCC as a tumor suppressor inhibits the progression of RCC cells in vitro. A Relative expression of SLERCC in different ccRCC cell lines. B Relative expression of SLERCC in 786-O cell lines transfected with PSPM-NPs or Vector. C Relative expression of SLERCC in ACHN cell lines transfected with sh-NC, sh-SLERCC#1, sh-SLERCC#2, or sh-SLERCC#3 constructs. D-E Growth curves of 786-O cells (D) and ACHN cells (E) were measured after transfection with indicated vectors by CCK-8 assays. F, L The migratory capacity of 786-O cells (F) and ACHN cells (L) transfected with indicated vectors assessed by the wound healing assay. G, M Cell migration and invasion of 786-O cells (G) and ACHN cells (M) transfected with indicated vectors assessed by Transwell migration and Matrigel invasion assays. H, K Growth curves of 786-O cells (H) and ACHN cells (K) transfected with indicated vectors assessed by EdU assays. (I, N) The angiogenic capacity of 786-O cells (I) and ACHN cells (N) transfected with indicated vectors assessed by tube formation assay. J, O Stemness of 786-O cells (J) and ACHN cells (O) transfected with indicated vectors assessed by the tumorsphere assay. (*p < 0.05, **p < 0.01, ***p < 0.001)