TABLE 2.
Outcomes of secondary endpoints.
| Outcomes | Types of Invention | Subgroup | Heterogeneity | Overall Effect | Statistical | Studies (N) | Participants(N) | Figures | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| I2 (%) | p | MD | 95%CI | p | Significant | Method | ||||||
| TJC-28 | IGU | MTX | 70 | 0.04 | -2.17 | [-2.92, -1.42] | <0.00001 | Yes | Random | 3 | 237 | S1 |
| IGU + MTX | MTX | 0 | 0.44 | -2.54 | [-2.69, -2.38] | <0.00001 | Yes | Random | 5 | 427 | S3 | |
| MTX + LEF | 32 | 0.22 | -0.14 | [-0.34,0.06] | 0.16 | No | 4 | 413 | ||||
| MTX + HCQ | 0 | -0.76 | [-0.94, -0.58] | <0.00001 | Yes | 1 | 146 | |||||
| MTX + TGs | 37 | 0.21 | -1.78 | [-2.33, -1.23] | <0.00001 | Yes | 2 | 160 | ||||
| Summary | 96 | <0.00001 | -1.40 | [-1.98, -0.81] | <0.0001 | Yes | 12 | 1146 | ||||
| SJC-28 | IGU | MTX | 90 | <0.0001 | -1.22 | [-1.40, -1.04] | <0.00001 | Yes | Random | 3 | 237 | S1 |
| IGU + MTX | MTX | 5 | 0.38 | -2.98 | [-3.11, -2.85] | <0.00001 | Yes | Random | 5 | 427 | S4 | |
| MTX + LEF | 73 | 0.01 | -0.09 | [-0.36, 0.18] | 0.50 | No | 4 | 413 | ||||
| MTX + HCQ | 0 | -1.30 | [-1.67, -0.93] | <0.00001 | Yes | 1 | 146 | |||||
| MTX + TGs | 55 | 0.14 | -1.99 | [-2.66, -1.33] | <0.00001 | Yes | 2 | 160 | ||||
| Summary | 99 | <0.00001 | -1.84 | [-2.81, -0.87] | 0.0002 | Yes | 12 | 1146 | ||||
| VAS | IGU | MTX | 0 | 0.45 | -5.61 | [-7.12, -4.11] | <0.00001 | No | Fixed | 3 | 234 | S2 |
| IGU + MTX | MTX | 0 | -5.30 | [-7.71, -2.89] | <0.0001 | Yes | Random | 1 | 60 | S5 | ||
| MTX + TGs | 0 | -0.21 | [-1.08, 0.06] | 0.64 | No | 1 | 60 | |||||
| Summary | 100 | <0.00001 | -2.63 | [-7.61, 2.36] | 0.30 | No | 2 | 180 | ||||
| PGA | IGU | MTX | 0 | 0.59 | -2.73 | [-3.52, -1.95] | <0.00001 | Yes | Fixed | 3 | 167 | S2 |
| IGU + MTX | MTX | 0 | 0.74 | -12.77 | [-13.40, -12.13] | <0.00001 | Yes | Fixed | 4 | 293 | S5 | |
| EGA | IGU | MTX | 0 | 0.85 | -3.27 | [-3.95, -2.59] | <0.00001 | Yes | Fixed | 3 | 234 | S2 |
| IGU + MTX | MTX | 73 | 0.01 | -5.08 | [-9.93, -0.82] | <0.00001 | Yes | Random | 4 | 275 | S5 | |
| HAQ | IGU | MTX | 0 | 0.89 | 0.00 | [-0.01, 0.01] | 0.96 | No | Fixed | 4 | 294 | S2 |
| IGU + MTX | MTX | 88 | <0.00001 | -0.17 | [-0.50, 0.17] | 0.34 | No | Random | 4 | 260 | S5 | |
| MTX + LEF | 0 | 0.00 | [-0.26, 0.26] | 1.00 | No | 1 | 144 | |||||
| Summary | 85 | <0.0001 | -0.13 | [-0.41, 0.14] | 0.34 | No | 5 | 404 | ||||
| ESR | IGU | MTX | 59 | 0.04 | -6.34 | [-6.89, -5.79] | <0.00001 | Yes | Random | 5 | 357 | S1 |
| IGU + MTX | MTX | 96 | <0.00001 | -15.27 | [-20.31, -10.23] | <0.00001 | Yes | Random | 11 | 815 | S6 | |
| MTX + LEF | 74 | 0.02 | -2.37 | [-9.64,4.90] | 0.52 | No | 3 | 324 | ||||
| MTX + HCQ | 0 | -6.61 | [-8.17, -5.05] | <0.00001 | Yes | 1 | 146 | |||||
| MTX + TGs | 52 | 0.12 | -5.91 | [-8.86, -2.95] | <0.0001 | Yes | 3 | 220 | ||||
| Summary | 97 | <0.00001 | -10.98 | [-15.01, -6.96] | <0.00001 | Yes | 18 | 1505 | ||||
| CRP | IGU | MTX | 96 | <0.00001 | -5.91 | [-9.45, -2.37] | 0.001 | Yes | Random | 5 | 357 | S1 |
| IGU + MTX | MTX | 95 | <0.00001 | -10.87 | [-14.31, -7.43] | <0.00001 | Yes | Random | 12 | 875 | S7 | |
| MTX + LEF | 44 | 0.18 | 2.15 | [-3.78,8.09] | 0.48 | No | 2 | 199 | ||||
| MTX + HCQ | 93 | 0.0001 | -4.17 | [-6.75, -1.58] | 0.002 | Yes | 2 | 206 | ||||
| MTX + TGs | 0 | 0.82 | -2.56 | [-4.14, -0.98] | 0.001 | Yes | 2 | 120 | ||||
| Summary | 97 | <0.00001 | -7.75 | [-10.41, -5.08] | <0.00001 | Yes | 18 | 1400 | ||||
| Anti-CCP | IGU | MTX | 0 | -13.00 | [-18.40, -7.60] | <0.00001 | Yes | Fixed | 1 | 53 | S2 | |
| IGU + MTX | MTX | 0 | 0.77 | -17.51 | [-22.66, -12.37] | <0.00001 | Yes | Fixed | 3 | 175 | S8 | |
| MTX + LEF | 0 | -125 | [-277.88, 27.88] | 0.11 | No | 1 | 142 | |||||
| MTX + TGs | 0 | -10.03 | [-78.49, 58.43] | 0.77 | No | 1 | 60 | |||||
| Summary | 0 | 0.65 | -17.59 | [-22.72, -12.46] | <0.00001 | Yes | 5 | 377 | ||||
| RF | IGU | MTX | 0 | 0.35 | -3.03 | [-7.69,1.63] | 0.20 | No | Fixed | 2 | 123 | S2 |
| IGU + MTX | MTX | 38 | 0.18 | -32.11 | [-34.54, -29.68] | <0.00001 | Yes | Random | 4 | 231 | S9 | |
| MTX + HCQ | 0 | -20.5 | [-24.18, -16.82] | <0.00001 | Yes | 1 | 146 | |||||
| MTX + TGs | 0 | -354.4 | [-435.91, -272.89] | <0.00001 | Yes | 1 | 60 | |||||
| Summary | 95 | <0.00001 | -31.66 | [-40.06, -23.26] | <0.00001 | Yes | 6 | 437 | ||||
| Morning stiffness | IGU | MTX | 98 | <0.00001 | -0.31 | [-0.35, -0.28] | <0.00001 | Yes | Random | 2 | 174 | S1 |
| IGU + MTX | MTX | 99 | <0.00001 | -4.05 | [-5.00, -3.09] | <0.00001 | Yes | Random | 8 | 686 | S10 | |
| MTX + LEF | 41 | 0.19 | -0.78 | [-4.00,2.44] | 0.63 | No | 2 | 205 | ||||
| MTX + TGs | 0 | -0.46 | [-0.80, -0.12] | 0.009 | Yes | 1 | 60 | |||||
| Summary | 98 | <0.00001 | -1.21 | [-1.70, -0.73] | <0.00001 | Yes | 10 | 951 | ||||