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. 2022 Aug 18;11(1):2111906. doi: 10.1080/2162402X.2022.2111906

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — High levels of COMP are associated with a worse prognosis of periampullary adenocarcinoma patient measured as overall survival (OS) and recurrence -free survival (RFS) in whole cohort due to high expression of COMP in morphologic PB-type. (a) Tissue microarrays including biopsies from 165 patients were stained for COMP. The intensity of staining was scored separately for cancer cells and stroma by two independent observers. (b) Patient were stratified in low (score 0–1) and high (score 2–3) COMP expressing groups. Kaplan Meier estimation of OS and RFS showed that high levels of COMP expression in cancer cells or in stroma correlated with shorter OS and RFS of patients. (c, d) OS and RFS survival analyses performed on I-type and PB-type separately. In I-type there was a tendency toward correlation of COMP expression with OS while such correlation was not found in PB-type.