Table 1.
Associations of clinicopathological characteristics with COMP expression.
| Cancer cells | Stroma cells | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Factor | COMP low |
COMP high |
p-value | COMP low |
COMP high |
p-value | ||||
| |
N |
(%) |
N |
(%) |
|
N |
(%) |
N |
(%) |
|
| All (N = 170) | 92 | 54.1 | 78 | 45.9 | 73 | 42.9 | 97 | 57.1 | ||
| Age at surgery | 0.832b | 0.349b | ||||||||
| <50 | 8 | 4.7% | 4 | 2.4% | 5 | 2.9% | 7 | 4.1% | ||
| 50–70 | 56 | 32.9% | 51 | 30.0% | 43 | 25.3% | 64 | 37.6% | ||
| >70 | 28 | 16.5% | 23 | 13.5% | 25 | 14.7% | 26 | 15.3% | ||
| Sex | 0.420a | 0.139a | ||||||||
| Female | 47 | 27.6% | 35 | 20.6% | 40 | 23.5% | 42 | 24.7% | ||
| Male | 45 | 26.5% | 43 | 25.3% | 33 | 19.4% | 55 | 32.4% | ||
| Morphological subtype | <0.0001a | <0.0001a | ||||||||
| Intestinal | 52 | 30.6% | 11 | 6.5% | 48 | 28.2% | 15 | 8.8% | ||
| Pancreatobiliary | 40 | 23.5% | 67 | 39.4% | 25 | 14.7% | 82 | 48.2% | ||
| Adjuvant vs no adjuvant | 0.002a | 0.001a | ||||||||
| No adjuvant | 61 | 35.9% | 33 | 19.4% | 51 | 30.0% | 43 | 25.3% | ||
| Adjuvant | 31 | 18.2% | 45 | 26.5% | 22 | 12.9% | 54 | 31.8% | ||
| Anatomical tumor origin | <0.0001b | <0.0001b | ||||||||
| Duodenum | 11 | 6.5% | 3 | 1.8% | 11 | 6.5% | 3 | 1.8% | ||
| Papilla-Ampulla Intestinal | 41 | 24.1% | 8 | 4.7% | 37 | 21.8% | 12 | 7.1% | ||
| Papilla-Ampulla Pancreatobiliary | 9 | 5.3% | 10 | 5.9% | 8 | 4.7% | 11 | 6.5% | ||
| Distal Bile Duct | 18 | 10.6% | 26 | 15.3% | 7 | 4.1% | 37 | 21.8% | ||
| Pancreas | 13 | 7.6% | 31 | 18.2% | 10 | 5.9% | 34 | 20.0% | ||
| Tumor size | <0.0001a | <0.0001a | ||||||||
| ≤ 20 mm | 31 | 18.2% | 7 | 4.1% | 28 | 16.5% | 10 | 5.9% | ||
| >20 mm | 61 | 35.9% | 71 | 41.8% | 45 | 26.5% | 87 | 51.2% | ||
| N-stage | 0.005a | 0.004a | ||||||||
| pN0 | 44 | 25.9% | 21 | 12.4% | 37 | 21.8% | 28 | 16.5% | ||
| pN1 | 48 | 28.2% | 57 | 33.5% | 36 | 21.2% | 69 | 40.6% | ||
| T-stage | 0.030a | 0.007a | ||||||||
| pT1-T2 | 21 | 12.4% | 8 | 4.7% | 19 | 11.2% | 10 | 5.9% | ||
| pT3-T4 | 71 | 41.8% | 70 | 41.2% | 54 | 31.8% | 87 | 51.2% | ||
| R-margin status | 0.013a | <0.0001a | ||||||||
| R0 | 18 | 10.6% | 5 | 2.9% | 18 | 10.6% | 5 | 2.9% | ||
| R1 or Rx | 74 | 43.5% | 73 | 42.9% | 55 | 32.4% | 92 | 54.1% | ||
| Perineural growth | <0.0001a | <0.0001a | ||||||||
| No growth | 56 | 32.9% | 12 | 7.1% | 51 | 30.0% | 17 | 10.0% | ||
| Perineural growth | 36 | 21.2% | 66 | 38.8% | 22 | 12.9% | 80 | 47.1% | ||
| Cancer in lymph vessels | 0.272a | 0.084a | ||||||||
| No cancer | 37 | 21.8% | 25 | 14.7% | 32 | 18.8% | 30 | 17.6% | ||
| Cancer | 55 | 32.4% | 53 | 31.2% | 41 | 24.1% | 67 | 39.4% | ||
| Cancer in blood vessels | 0.041a | 0.001a | ||||||||
| No cancer | 75 | 44.1% | 53 | 31.2% | 64 | 37.6% | 64 | 37.6% | ||
| Cancer | 17 | 10.0% | 25 | 14.7% | 9 | 5.3% | 33 | 19.4% | ||
| Growth in peripancreatic fat | <0.0001a | <0.0001a | ||||||||
| No growth | 50 | 29.4% | 14 | 8.2% | 47 | 27.6% | 17 | 10.0% | ||
| Growth | 42 | 24.7% | 64 | 37.6% | 26 | 15.3% | 80 | 47.1% | ||
Abbreviations: COMP, cartilage oligomeric matrix protein; The bold indicates p-values <0.05. aMann–Whitney two-tailed Exact p-value, bKruskal-Wallis p-value.