Table 3.
Hazard ratios for incident outcomes associated with polygenic risk tier and frequency of depressed mood.
| Coronary artery disease | Type 2 diabetes mellitus | Atrial fibrillation | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | ||||||||
| Poly-genic risk tier | Frequency of depressed mood | Hazard ratio (95% CI) |
P-value | Hazard ratio (95% CI) |
P-value | Hazard ratio (95% CI) |
P-value | Hazard ratio (95% CI) |
P-value | Hazard ratio (95% CI) |
P-value | Hazard ratio (95% CI) |
P-value |
| Low | Low | 1.00 (reference) |
-- | 1.00 (reference) |
-- | 1.00 (reference) |
-- | 1.00 (reference) |
-- | 1.00 (reference) |
-- | 1.00 (reference) |
-- |
| Moderate | 1.34 (1.21–1.49) |
1.8x10−8 | 1.27 (1.13–1.43) |
4.3x10−5 | 1.28 (1.11–1.46) |
4.4x10−4 | 1.18 (1.01–1.38) |
0.03 | 1.31 (1.17–1.48) |
6.5x10−6 | 1.24 (1.08–1.42) |
0.002 | |
| High | 2.12 (1.79–2.51) |
<2x10−16 | 1.81 (1.49–2.19) |
1.0x10−9 | 2.26 (1.84–2.77) |
8.5x10−15 | 1.50 (1.19–1.91) |
7.5x10−4 | 1.33 (1.04–1.69) |
0.02 | 1.20 (0.91–1.58) |
0.19 | |
| Inter-mediate | Low | 1.51 (1.44–1.59) |
<2x10−16 | 1.43 (1.35–1.52) |
<2x10−16 | 2.03 (1.90–2.17) |
<2x10−16 | 1.71 (1.59–1.85) |
<2x10−16 | 1.69 (1.59–1.79) |
<2x10−16 | 1.72 (1.61–1.83) |
<2x10−16 |
| Moderate | 1.97 (1.85–2.10) |
<2x10−16 | 1.70 (1.58–1.83) |
<2x10−16 | 2.71 (2.51–2.94) |
<2x10−16 | 2.02 (1.85–2.20) |
<2x10−16 | 1.87 (1.73–2.01) |
<2x10−16 | 1.81 (1.66–1.96) |
<2x10−16 | |
| High | 2.78 (2.53–3.06) |
<2x10−16 | 2.15 (1.93–2.40) |
<2x10−16 | 4.01 (3.60–4.45) |
<2x10−16 | 2.59 (2.29–2.91) |
<2x10−16 | 2.44 (2.18–2.74) |
<2x10−16 | 2.25 (1.98–2.55) |
<2x10−16 | |
| High | Low | 2.42 (2.29–2.56) |
<2x10−16 | 2.18 (2.05–2.32) |
<2x10−16 | 3.90 (3.64–4.18) |
<2x10−16 | 2.61 (2.41–2.82) |
<2x10−16 | 2.99 (2.81–3.17) |
<2x10−16 | 3.04 (2.84–3.25) |
<2x10−16 |
| Moderate | 2.93 (2.71–3.18) |
<2x10−16 | 2.43 (2.22–2.66) |
<2x10−16 | 4.93 (4.50–5.39) |
<2x10−16 | 3.13 (2.83–3.46) |
<2x10−16 | 3.18 (2.91–3.47) |
<2x10−16 | 3.11 (2.81–3.43) |
<2x10−16 | |
| High | 4.03 (3.54–4.60) |
<2x10−16 | 3.11 (2.69–3.59) |
<2x10−16 | 7.83 (6.90–8.90) |
<2x10−16 | 3.82 (3.31–4.40) |
<2x10−16 | 3.82 (3.28–4.43) |
<2x10−−16 | 3.51 (2.97–4.15) |
<2x10−16 | |
Two-sided P-values (unadjusted for multiple comparisons) were calculated using multivariable-adjusted Cox proportional hazard models. Model 1: Adjusted for age, age2, sex, PC 1–20, genotyping array, country, Townsend deprivation index
Model 2: Adjusted for age, age2, sex, PC 1–20, genotyping array, country, Townsend deprivation index, smoking status, pack-year smoking history, alcohol intake, vegetable + fresh fruit intake, days per week of moderate and vigorous exercise, sleep duration, systolic blood pressure, antihypertensive medication use, non-HDL cholesterol, cholesterol-lowering medication use, antiplatelet medication use, antihyperglycemic medication use, prevalent type 2 diabetes mellitus, body-mass index, C-reactive protein