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. 2022 Aug 19;12:14173. doi: 10.1038/s41598-022-18448-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MALDI ToF MS of Sequentially Labeled α2,3- and α2,6-linked Sialyl N-glycans. N-glycans derived from HL60 (top panel) and dHL60 (bottom panel) cells were sequentially labeled by esterification and amidation of α2,3- and α2,6-linked SA, respectively. The α2,6-linked SA substituted N-glycans were dramatically increased in dHL60 cells. Cartoonized structures shown with the α2,6- label denote exclusive substitution with α2,6-linked SA whereas those denoted as mixed contain both α2,3- and α2,6-linked SA substitutions. Symbols represent the following monosaccharides: Blue square, GlcNAc; Green circle, Man; Yellow circle, Gal; Pink diamond, NeuAc. These data are representative of 2 independent experiments.