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. 2022 Feb 24;10:222–242. doi: 10.1016/j.xjon.2022.02.027

Figure 8.

Figure 8

Key study methods, results, and implications. A, Left ventricular diastolic function (mitral E/A ratio) measured from echocardiography; B, changes in myocardial angiogenesis (microvessel density measured from the biotinylated-isolectin B4-stained mouse hearts); C, effects of macrophage depletion with clodronate-liposome on myocardial angiogenesis in the mice subjected to transverse aortic constriction (TAC) and cardio-omentopexy (COP). Control mice were subjected to sham TAC surgery for 6 weeks and subsequent sham COP surgery for 8 weeks. COP mice were subjected to sham TAC surgery for 6 weeks and subsequent COP for 8 weeks. TAC mice underwent TAC for 6 weeks and subsequent sham COP surgery for 8 weeks. TAC+COP mice were subjected to TAC for 6 weeks and subsequent COP for 8 weeks. The lower and upper borders of the box represent the lower and upper quartiles (25th percentile and 75th percentile). The middle horizontal line represents the median. The lower and upper whiskers represent the minimum and maximum values of nonoutliers. Larger extra dots represent outliers.