Table 1.
The overview of each point KRAS mutation across cancer types
|
Location
|
KRAS
Mutation and Cancer Type |
Others
|
Total
|
|||||||||||||||||||
|
G12
|
G13
|
Q61
|
||||||||||||||||||||
|
12A
|
12C
|
12D
|
12R
|
12S
|
12V
|
Others
|
13A
|
13C
|
13D
|
13R
|
13S
|
13V
|
Others
|
61H
|
61K
|
61L
|
61P
|
61R
|
Others
|
|||
| Anus | 2 | 1 | 6 | 4 | 1 | 14 | ||||||||||||||||
| Anal squamous cell carcinoma | 2 | 1 | 6 | 4 | 1 | 14 | ||||||||||||||||
| Biliary tract | 41 | 60 | 428 | 34 | 72 | 181 | 10 | 7 | 47 | 4 | 3 | 3 | 3 | 20 | 5 | 1 | 6 | 29 | 954 | |||
| Bile duct carcinoma | 38 | 55 | 331 | 24 | 55 | 164 | 10 | 5 | 37 | 2 | 3 | 3 | 2 | 17 | 5 | 1 | 6 | 25 | 783 | |||
| Bile duct carcinoma intraductal papillary neoplasm | 2 | 16 | 2 | 1 | 1 | 2 | 3 | 27 | ||||||||||||||
| Bile duct intraepithelial neoplasia | 13 | 1 | 14 | |||||||||||||||||||
| Gallbladder carcinoma | 1 | 5 | 68 | 10 | 17 | 14 | 1 | 9 | 2 | 1 | 1 | 1 | 130 | |||||||||
| Breast | 9 | 13 | 25 | 10 | 6 | 22 | 1 | 1 | 17 | 2 | 1 | 4 | 41 | 152 | ||||||||
| Carcinoma | 9 | 13 | 25 | 10 | 6 | 22 | 1 | 1 | 17 | 2 | 1 | 4 | 41 | 152 | ||||||||
| Central nervous system | 8 | 1 | 10 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 10 | 40 | |||||||||
| Glioma | 8 | 1 | 10 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 10 | 40 | |||||||||
| Cervix | 5 | 13 | 55 | 3 | 21 | 26 | 18 | 1 | 4 | 2 | 1 | 16 | 165 | |||||||||
| Carcinoma | 5 | 13 | 55 | 3 | 21 | 26 | 18 | 1 | 4 | 2 | 1 | 16 | 165 | |||||||||
| Colorectal | 271 | 420 | 1781 | 54 | 293 | 1116 | 9 | 33 | 1031 | 14 | 2 | 9 | 10 | 59 | 16 | 15 | 1 | 14 | 278 | 5426 | ||
| Anorectal adenocarcinoma | 5 | 1 | 1 | 1 | 2 | 2 | 1 | 13 | ||||||||||||||
| Colon adenocarcinoma | 207 | 326 | 1328 | 38 | 207 | 838 | 3 | 19 | 762 | 7 | 1 | 5 | 5 | 41 | 13 | 6 | 1 | 7 | 201 | 4015 | ||
| Rectal adenocarcinoma | 64 | 94 | 448 | 15 | 85 | 277 | 6 | 14 | 267 | 7 | 1 | 4 | 5 | 16 | 3 | 8 | 7 | 77 | 1398 | |||
| Endometrium | 74 | 59 | 241 | 3 | 20 | 157 | 2 | 12 | 78 | 1 | 2 | 3 | 6 | 4 | 49 | 711 | ||||||
| Carcinoma | 74 | 59 | 241 | 3 | 20 | 157 | 2 | 12 | 78 | 1 | 2 | 3 | 6 | 4 | 49 | 711 | ||||||
| Esophagus | 1 | 3 | 16 | 1 | 3 | 7 | 1 | 10 | 1 | 30 | 73 | |||||||||||
| Adenocarcinoma | 1 | 2 | 8 | 3 | 5 | 1 | 8 | 18 | 46 | |||||||||||||
| Squamous cell carcinoma | 1 | 8 | 1 | 2 | 2 | 1 | 12 | 27 | ||||||||||||||
| Germ cell tumor | 7 | 5 | 10 | 7 | 4 | 31 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 19 | 96 | ||||||
| Extragonadal | 2 | 1 | 3 | 2 | 8 | 2 | 1 | 5 | 13 | 37 | ||||||||||||
| Testicular | 5 | 4 | 7 | 7 | 2 | 23 | 1 | 1 | 1 | 1 | 1 | 6 | 59 | |||||||||
| Hematopoietic and lymphoid | 77 | 34 | 284 | 33 | 60 | 102 | 4 | 2 | 15 | 288 | 1 | 1 | 9 | 72 | 3 | 6 | 13 | 13 | 1 | 277 | 1295 | |
| Hematopoietic neoplasm | 36 | 15 | 144 | 17 | 32 | 49 | 2 | 1 | 9 | 129 | 7 | 24 | 1 | 5 | 5 | 2 | 107 | 585 | ||||
| Lymphoid neoplasm | 41 | 19 | 140 | 16 | 28 | 53 | 2 | 1 | 6 | 159 | 1 | 1 | 2 | 48 | 2 | 1 | 8 | 11 | 1 | 170 | 710 | |
| Kidney | 5 | 8 | 1 | 7 | 5 | 1 | 1 | 1 | 1 | 2 | 32 | |||||||||||
| Carcinoma | 5 | 8 | 1 | 7 | 5 | 1 | 1 | 1 | 1 | 2 | 32 | |||||||||||
| Liver | 4 | 19 | 4 | 2 | 6 | 1 | 6 | 43 | 85 | |||||||||||||
| Carcinoma | 4 | 19 | 4 | 2 | 6 | 1 | 6 | 43 | 85 | |||||||||||||
| Lung | 550 | 2578 | 1342 | 106 | 206 | 1543 | 42 | 4 | 206 | 212 | 7 | 6 | 7 | 6 | 64 | 13 | 20 | 2 | 11 | 4 | 58 | 6987 |
| Adenocarcinoma | 355 | 1425 | 715 | 48 | 107 | 879 | 28 | 3 | 108 | 129 | 2 | 4 | 4 | 2 | 38 | 5 | 13 | 4 | 38 | 3907 | ||
| Bronchioloalveolar adenocarcinoma | 10 | 42 | 69 | 2 | 3 | 47 | 1 | 3 | 177 | |||||||||||||
| Invasive mucinous adenocarcinoma | 1 | 11 | 22 | 1 | 3 | 26 | 1 | 1 | 66 | |||||||||||||
| Large cell carcinoma | 9 | 52 | 17 | 2 | 5 | 38 | 1 | 5 | 3 | 1 | 8 | 1 | 3 | 1 | 146 | |||||||
| Mixed adenosquamous carcinoma | 1 | 18 | 8 | 3 | 5 | 1 | 7 | 2 | 45 | |||||||||||||
| Neuroendocrine tumor | 2 | 3 | 1 | 2 | 8 | 1 | 4 | 21 | ||||||||||||||
| Non–small cell carcinoma | 149 | 915 | 434 | 44 | 72 | 480 | 10 | 87 | 64 | 4 | 1 | 3 | 4 | 12 | 5 | 3 | 1 | 5 | 1 | 5 | 2299 | |
| Pleomorphic carcinoma | 9 | 16 | 5 | 10 | 1 | 41 | ||||||||||||||||
| Sarcomatoid carcinoma | 3 | 37 | 14 | 1 | 17 | 1 | 2 | 1 | 76 | |||||||||||||
| Squamous cell carcinoma | 11 | 54 | 55 | 7 | 10 | 31 | 1 | 2 | 5 | 1 | 3 | 1 | 1 | 1 | 2 | 3 | 9 | 197 | ||||
| Undifferentiated carcinoma | 2 | 6 | 1 | 2 | 1 | 12 | ||||||||||||||||
| Melanoma | 3 | 4 | 12 | 4 | 8 | 11 | 2 | 1 | 14 | 1 | 1 | 2 | 7 | 1 | 5 | 35 | 111 | |||||
| Malignant melanoma | 3 | 4 | 12 | 4 | 8 | 11 | 2 | 1 | 14 | 1 | 1 | 2 | 7 | 1 | 5 | 35 | 111 | |||||
| Ovary | 40 | 36 | 278 | 35 | 14 | 264 | 4 | 9 | 48 | 1 | 2 | 1 | 9 | 3 | 23 | 767 | ||||||
| Carcinoma | 34 | 25 | 243 | 30 | 14 | 231 | 4 | 7 | 43 | 1 | 2 | 1 | 9 | 3 | 21 | 668 | ||||||
| Others | 6 | 11 | 35 | 5 | 33 | 2 | 5 | 2 | 99 | |||||||||||||
| Pancreas | 82 | 160 | 3097 | 835 | 99 | 2169 | 21 | 3 | 5 | 73 | 5 | 7 | 2 | 4 | 102 | 9 | 15 | 1 | 40 | 2 | 51 | 6782 |
| Ductal carcinoma | 79 | 133 | 2760 | 738 | 85 | 1867 | 16 | 3 | 5 | 56 | 5 | 5 | 2 | 4 | 87 | 9 | 8 | 1 | 26 | 2 | 42 | 5933 |
| Dysplasia-in situ neoplasm | 2 | 17 | 281 | 77 | 12 | 244 | 1 | 17 | 2 | 11 | 6 | 14 | 4 | 688 | ||||||||
| Neuroendocrine tumor | 1 | 3 | 3 | 2 | 4 | 1 | 5 | 19 | ||||||||||||||
| Osteoclast-like giant cell carcinoma | 2 | 8 | 3 | 2 | 7 | 22 | ||||||||||||||||
| Pancreatic intraepithelial neoplasia (PanIN) | 8 | 45 | 14 | 49 | 3 | 1 | 120 | |||||||||||||||
| Prostate | 2 | 10 | 23 | 3 | 3 | 41 | 23 | 3 | 1 | 7 | 4 | 1 | 19 | 140 | ||||||||
| Adenocarcinoma | 2 | 10 | 23 | 3 | 3 | 41 | 23 | 3 | 1 | 7 | 4 | 1 | 19 | 140 | ||||||||
| Salivary gland | 1 | 1 | 1 | 1 | 6 | 10 | ||||||||||||||||
| Carcinoma | 1 | 1 | 1 | 1 | 6 | 10 | ||||||||||||||||
| Skin | 7 | 13 | 1 | 1 | 6 | 1 | 1 | 24 | 54 | |||||||||||||
| Carcinoma | 7 | 13 | 1 | 1 | 6 | 1 | 1 | 24 | 54 | |||||||||||||
| Small intestine | 15 | 13 | 94 | 4 | 11 | 37 | 40 | 1 | 1 | 2 | 1 | 10 | 229 | |||||||||
| Adenocarcinoma | 15 | 13 | 94 | 4 | 11 | 37 | 40 | 1 | 1 | 2 | 1 | 10 | 229 | |||||||||
| Soft tissue | 3 | 15 | 21 | 4 | 1 | 1 | 33 | 3 | 1 | 1 | 2 | 85 | ||||||||||
| Angiosarcoma | 6 | 11 | 1 | 1 | 11 | 2 | 32 | |||||||||||||||
| Leiomyosarcoma | 4 | 2 | 1 | 1 | 1 | 1 | 10 | |||||||||||||||
| Pleomorphic sarcoma | 1 | 2 | 18 | 21 | ||||||||||||||||||
| Rhabdomyosarcoma | 3 | 5 | 7 | 3 | 1 | 1 | 2 | 22 | ||||||||||||||
| Stomach | 13 | 12 | 97 | 8 | 29 | 2 | 61 | 11 | 1 | 1 | 4 | 3 | 2 | 3 | 30 | 277 | ||||||
| Adenocarcinoma | 13 | 12 | 97 | 8 | 29 | 2 | 61 | 11 | 1 | 1 | 4 | 3 | 2 | 3 | 30 | 277 | ||||||
| Thyroid | 4 | 20 | 38 | 30 | 20 | 22 | 1 | 1 | 24 | 2 | 11 | 2 | 8 | 3 | 3 | 40 | 10 | 239 | ||||
| Anaplastic carcinoma | 2 | 12 | 15 | 3 | 9 | 6 | 11 | 4 | 1 | 11 | 1 | 75 | ||||||||||
| Follicular carcinoma | 1 | 3 | 3 | 1 | 3 | 5 | 7 | 1 | 1 | 2 | 10 | 37 | ||||||||||
| Medullary carcinoma | 24 | 2 | 4 | 1 | 1 | 2 | 2 | 2 | 3 | 5 | 46 | |||||||||||
| Mixed papillary and follicular carcinoma | 8 | 4 | 12 | |||||||||||||||||||
| Papillary carcinoma | 1 | 5 | 12 | 2 | 6 | 7 | 1 | 1 | 5 | 2 | 1 | 4 | 1 | 1 | 16 | 4 | 69 | |||||
| Unknown primary | 4 | 14 | 9 | 2 | 12 | 2 | 1 | 5 | 1 | 1 | 3 | 54 | ||||||||||
| Carcinoma | 4 | 14 | 9 | 2 | 12 | 2 | 1 | 5 | 1 | 1 | 3 | 54 | ||||||||||
| Upper aerodigestive tract | 3 | 7 | 31 | 1 | 7 | 2 | 2 | 8 | 1 | 1 | 1 | 1 | 1 | 22 | 88 | |||||||
| Adenocarcinoma | 1 | 19 | 1 | 1 | 1 | 5 | 1 | 29 | ||||||||||||||
| Squamous cell carcinoma | 3 | 6 | 12 | 1 | 6 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 22 | 59 | ||||||||
| Urinary tract | 10 | 20 | 44 | 11 | 7 | 32 | 13 | 1 | 3 | 2 | 3 | 21 | 167 | |||||||||
| Adenocarcinoma | 1 | 7 | 2 | 1 | 8 | 7 | 1 | 5 | 32 | |||||||||||||
| Carcinoma, unclassified | 2 | 7 | 11 | 3 | 6 | 2 | 1 | 1 | 1 | 5 | 39 | |||||||||||
| Transitional cell carcinoma | 7 | 13 | 26 | 6 | 6 | 18 | 4 | 1 | 2 | 1 | 1 | 11 | 96 | |||||||||
| Total | 1224 | 3514 | 7983 | 1179 | 865 | 5830 | 92 | 16 | 299 | 2058 | 35 | 52 | 30 | 42 | 362 | 66 | 98 | 26 | 137 | 16 | 1109 | 25,033 |
Data were extracted from the COSMIC database (version 95 released Mar 31, 2022). The number of tumors with a point mutation on the KRAS isoform is indicated in the table. Subtypes of tumors with the number of fewer than 10, benign tumors, and tumors with undetermined primary sites and unclear histology were removed from this analysis.
Bold values are the totals by location, mutation, and cancer type.
KRAS: Kirsten rat sarcoma viral oncogene homologue.