Table E3.
Modern subcohort baseline patient characteristics stratified by presence and location of obstructive CAD
| All (N = 273) |
No CAD (N = 242) |
Only anomalous coronary with CAD (N = 19) |
Normal- origin coronary with CAD (N = 12) |
P value | |
|---|---|---|---|---|---|
| Mean ± SD or n (%) |
Mean ± SD or n (%) |
Mean ± SD or n (%) |
Mean ± SD or n (%) |
||
| Demographics | |||||
| Age at CAD imaging, y | 52.5 ± 17.5 | 50.7 ± 17.3 | 64.1 ± 9.72 | 70.9 ± 13.6 | <.0001 |
| Male | 155 (57) | 95 (39) | 9 (47) | 7 (58) | .03 |
| Indication for diagnostic AAOCA imaging | |||||
| Symptomatic cardiac evaluation | 195 (71) | 175 (72) | 13 (68) | 7 (58) | .55 |
| Cardiac surgery evaluation | 45 (16) | 37 (15) | 5 (26) | 3 (25) | .33 |
| Noncardiac surgery evaluation | 13 (4.8) | 12 (5) | 0 (0) | 1 (8.3) | .52 |
| Noncoronary imaging | 7 (2.6) | 7 (2.9) | 0 (0) | 0 (0) | .63 |
| Routine screening | 3 (1.1) | 2 (0.83) | 0 (0) | 1 (8.3) | .046 |
| Other | 7 (2.6) | 6 (2.5) | 1 (5.3) | 0 (0) | .65 |
| Unknown | 3 (1.1) | 3 (1.2) | 0 (0) | 0 (0) | .82 |
| Symptoms | |||||
| Chest pain | 169 (62) | 147 (61) | 13 (68) | 9 (75) | .51 |
| Dyspnea | 181 (66) | 161 (67) | 12 (63) | 8 (67) | .96 |
| Syncope | 46 (17) | 43 (18) | 3 (16) | 0 (0) | .27 |
| Arrhythmia | 159 (58) | 143 (59) | 9 (47) | 7 (58) | .61 |
| Myocardial infarction | 25 (9.2) | 16 (6.6) | 5 (26) | 4 (33) | .0002 |
| Aborted SCD | 6 (2.2) | 5 (2.1) | 1 (5.3) | 0 (0) | .57 |
| None | 18 (6.6) | 13 (5.4) | 3 (16) | 2 (17) | .075 |
| Comorbidities | |||||
| Valve dysfunction | 128 (47) | 110 (45) | 10 (53) | 8 (67) | .31 |
| Cardiomyopathy | 36 (13) | 32 (13) | 2 (11) | 2 (17) | .88 |
| Heart failure | 68 (25) | 58 (24) | 5 (26) | 5 (42) | .38 |
| Arrhythmia | 165 (60) | 147 (61) | 10 (53) | 8 (67) | .71 |
| Congenital heart disease | 35 (13) | 32 (13) | 2 (11) | 1 (8.3) | .84 |
| Cerebrovascular disease | 21 (7.7) | 18 (7.4) | 2 (11) | 1 (8.3) | .89 |
| Pulmonary disease | 81 (30) | 74 (31) | 4 (21) | 3 (25) | .64 |
| Liver disease | 54 (20) | 45 (19) | 5 (26) | 4 (33) | .35 |
| Renal disease | 32 (12) | 25 (10) | 5 (26) | 2 (17) | .098 |
| Diabetes | 58 (21) | 44 (18) | 9 (47) | 5 (42) | .0024 |
| Peripheral arterial disease | 11 (4) | 9 (3.7) | 1 (5.3) | 1 (8.3) | .7 |
| Hypertension | 195 (71) | 168 (69) | 16 (84) | 11 (92) | .11 |
| Hyperlipidemia | 168 (62) | 140 (58) | 17 (89) | 11 (92) | .0022 |
| Tobacco use | 89 (33) | 77 (32) | 8 (42) | 4 (33) | .65 |
| None | 42 (15) | 42 (17) | 0 (0) | 0 (0) | .042 |
P values compared the CAD-free, CAD-only, and all-others categories. Origin refers to that of the anomalous coronary. Symptoms and comorbidities were not mutually exclusive. CAD, Coronary artery disease; AAOCA, anomalous aortic origin of a coronary artery; SCD, sudden cardiac death.